U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Has1 hyaluronan synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 15116, updated on 28-Dec-2022

Summary

Official Symbol
Has1provided by MGI
Official Full Name
hyaluronan synthase 1provided by MGI
Primary source
MGI:MGI:106590
See related
Ensembl:ENSMUSG00000003665 AllianceGenome:MGI:106590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HAS
Summary
Enables hyaluronan synthase activity. Involved in extracellular matrix assembly and extracellular polysaccharide biosynthetic process. Acts upstream of or within hyaluronan biosynthetic process. Located in cytoplasm and membrane. Is expressed in several structures, including alimentary system epithelium; face; gonad; heart; and skin. Orthologous to human HAS1 (hyaluronan synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 1.3), lung adult (RPKM 1.2) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Has1 in Genome Data Viewer
Location:
17 A3.2; 17 10.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (18063588..18075450, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (17833691..17855589, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene microRNA let7e Neighboring gene microRNA 125a Neighboring gene predicted gene, 36907 Neighboring gene formyl peptide receptor 1 Neighboring gene formyl peptide receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC159127, MGC159129

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hyaluronan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hyaluronan synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hyaluronan synthase 1
Names
HA synthase 1
hyaluronan synthase1
hyaluronate synthase 1
hyaluronic acid synthase 1
NP_032241.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008215.2NP_032241.1  hyaluronan synthase 1

    See identical proteins and their annotated locations for NP_032241.1

    Status: VALIDATED

    Source sequence(s)
    AK138203, AW488161, D82964
    Consensus CDS
    CCDS37459.1
    UniProtKB/Swiss-Prot
    Q61647
    UniProtKB/TrEMBL
    Q3UUP6
    Related
    ENSMUSP00000003762.7, ENSMUST00000003762.8
    Conserved Domains (2) summary
    TIGR04242
    Location:51493
    nodulat_NodC; chitooligosaccharide synthase NodC
    cl11394
    Location:100391
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    18063588..18075450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)