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Hars histidyl-tRNA synthetase [ Mus musculus (house mouse) ]

Gene ID: 15115, updated on 12-Aug-2019

Summary

Official Symbol
Harsprovided by MGI
Official Full Name
histidyl-tRNA synthetaseprovided by MGI
Primary source
MGI:MGI:108087
See related
Ensembl:ENSMUSG00000001380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMHRS
Expression
Ubiquitous expression in liver E14 (RPKM 39.6), liver E14.5 (RPKM 33.2) and 28 other tissues See more
Orthologs

Genomic context

See Hars in Genome Data Viewer
Location:
18; 18 B2
Exon count:
13
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36766528..36783205, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (36926182..36942859, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene histidyl-tRNA synthetase 2 Neighboring gene zinc finger, matrin type 2 Neighboring gene vault RNA component 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
histidine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
histidyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
histidine--tRNA ligase, cytoplasmic
Names
hisRS
histidine tRNA ligase
histidyl-tRNA synthetase, cytoplasmic
NP_032240.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008214.4NP_032240.3  histidine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_032240.3

    Status: VALIDATED

    Source sequence(s)
    AI849599, AK166826, CA561201
    Consensus CDS
    CCDS29164.1
    UniProtKB/Swiss-Prot
    Q61035
    Related
    ENSMUSP00000001416.6, ENSMUST00000001416.7
    Conserved Domains (4) summary
    COG0124
    Location:56501
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00773
    Location:69394
    HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00859
    Location:408499
    HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
    cd00938
    Location:549
    HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p6 C57BL/6J

    Range
    36766528..36783205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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