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Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 [ Mus musculus (house mouse) ]

Gene ID: 15108, updated on 1-Mar-2024

Summary

Official Symbol
Hsd17b10provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 10provided by MGI
Primary source
MGI:MGI:1333871
See related
Ensembl:ENSMUSG00000025260 AllianceGenome:MGI:1333871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ads9; ERAB; MHBD; Hadh2; 17bHSD10
Summary
Predicted to enable several functions, including amyloid-beta binding activity; estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular hormone metabolic process; and mitochondrial tRNA processing. Predicted to act upstream of or within steroid metabolic process and tRNA processing. Located in endoplasmic reticulum and mitochondrial nucleoid. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in chromosome Xp11.22 duplication syndrome; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 56.1), liver adult (RPKM 49.1) and 28 other tissues See more
Orthologs
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Genomic context

See Hsd17b10 in Genome Data Viewer
Location:
X F3; X 68.46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (150784892..150787438)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (152001896..152004442)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene HECT, UBA and WWE domain containing 1 Neighboring gene microRNA 98 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_48089 Neighboring gene predicted gene, 39540 Neighboring gene RIB43A domain with coiled-coils 1 Neighboring gene structural maintenance of chromosomes 1A Neighboring gene predicted gene 15267

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3-hydroxyacyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables acetoacetyl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables androstan-3-alpha,17-beta-diol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables cholate 7-alpha-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables testosterone dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables testosterone dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
 
enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in C21-steroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in androgen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in brexanolone metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in estrogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in isoleucine catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial tRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial tRNA 5'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial tRNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of tRNA methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-hydroxyacyl-CoA dehydrogenase type-2
Names
17-beta-HSD 10
17-beta-estradiol 17-dehydrogenase
17-beta-hydroxysteroid dehydrogenase 10
2-methyl-3-hydroxybutyryl-CoA dehydrogenase
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))
3-hydroxy-2-methylbutyryl-CoA dehydrogenase
3-hydroxyacyl-CoA dehydrogenase type II
3alpha(or 20beta)-hydroxysteroid dehydrogenase
7-alpha-hydroxysteroid dehydrogenase
endoplasmic reticulum-associated amyloid beta-peptide-binding protein
hydroxyacyl-Coenzyme A dehydrogenase, type II
mitochondrial RNase P protein 2
mitochondrial ribonuclease P protein 2
short chain dehydrogenase/reductase family 5C member 1
short-chain type dehydrogenase/reductase XH98G2
type II HADH
NP_058043.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016763.2NP_058043.3  3-hydroxyacyl-CoA dehydrogenase type-2

    See identical proteins and their annotated locations for NP_058043.3

    Status: VALIDATED

    Source sequence(s)
    BC027517
    Consensus CDS
    CCDS30471.1
    UniProtKB/TrEMBL
    Q99N15, Q9CYT3
    Related
    ENSMUSP00000026289.4, ENSMUST00000026289.10
    Conserved Domains (2) summary
    cd05371
    Location:9261
    HSD10-like_SDR_c; 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs
    PRK05557
    Location:7260
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    150784892..150787438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)