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PLB1 phospholipase B1 [ Homo sapiens (human) ]

Gene ID: 151056, updated on 25-Nov-2021

Summary

Official Symbol
PLB1provided by HGNC
Official Full Name
phospholipase B1provided by HGNC
Primary source
HGNC:HGNC:30041
See related
Ensembl:ENSG00000163803 MIM:610179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLB; PLB/LIP
Summary
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]
Expression
Biased expression in small intestine (RPKM 8.9), bone marrow (RPKM 1.8) and 8 other tissues See more
Orthologs
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Genomic context

See PLB1 in Genome Data Viewer
Location:
2p23.2
Exon count:
58
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (28496060..28644142)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (28718927..28867008)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723530 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 15095 Neighboring gene Sharpr-MPRA regulatory region 13650 Neighboring gene Sharpr-MPRA regulatory region 1316 Neighboring gene Sharpr-MPRA regulatory region 9151 Neighboring gene uncharacterized LOC105374384 Neighboring gene RNA, 5S ribosomal pseudogene 89

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 activity TAS
Traceable Author Statement
more info
 
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables retinyl-palmitate esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables retinyl-palmitate esterase activity TAS
Traceable Author Statement
more info
 
enables triglyceride lipase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in diacylglycerol catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phosphatidylcholine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylethanolamine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylglycerol catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of acrosome reaction IEA
Inferred from Electronic Annotation
more info
 
involved_in retinoid metabolic process TAS
Traceable Author Statement
more info
 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phospholipase B1, membrane-associated
Names
lysophospholipase
phospholipase A2
phospholipase B/lipase
triacylglycerol lipase
NP_001164056.1
NP_694566.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051297.1 RefSeqGene

    Range
    12482..160564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170585.2NP_001164056.1  phospholipase B1, membrane-associated isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC074011, AC093164, BC150633, BC153864, BX109719
    Consensus CDS
    CCDS54340.1
    UniProtKB/Swiss-Prot
    Q6P1J6
    UniProtKB/TrEMBL
    B2RWP8
    Related
    ENSP00000416440.2, ENST00000422425.6
    Conserved Domains (1) summary
    cd01824
    Location:10741360
    Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
  2. NM_153021.5NP_694566.4  phospholipase B1, membrane-associated isoform 1 precursor

    See identical proteins and their annotated locations for NP_694566.4

    Status: REVIEWED

    Source sequence(s)
    AC074011, AC093164, BC150633, BC153864, BX109719
    Consensus CDS
    CCDS33168.1
    UniProtKB/Swiss-Prot
    Q6P1J6
    UniProtKB/TrEMBL
    B2RWP8
    Related
    ENSP00000330442.5, ENST00000327757.10
    Conserved Domains (1) summary
    cd01824
    Location:382677
    Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...

RNA

  1. NR_138141.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC074011, KF510808

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    28496060..28644142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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