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KANSL1L KAT8 regulatory NSL complex subunit 1 like [ Homo sapiens (human) ]

Gene ID: 151050, updated on 21-Dec-2019

Summary

Official Symbol
KANSL1Lprovided by HGNC
Official Full Name
KAT8 regulatory NSL complex subunit 1 likeprovided by HGNC
Primary source
HGNC:HGNC:26310
See related
Ensembl:ENSG00000144445 MIM:613833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSL1v2; C2orf67
Expression
Ubiquitous expression in testis (RPKM 5.3), ovary (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See KANSL1L in Genome Data Viewer
Location:
2q34
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (210021421..210171409, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (210885435..211036068, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microtubule associated protein 2 Neighboring gene RNA, 5S ribosomal pseudogene 118 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene snail family zinc finger 1 pseudogene 1 Neighboring gene KANSL1L antisense RNA 1 Neighboring gene uncharacterized LOC112268429 Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene uncharacterized LOC107985977 Neighboring gene ribosomal protein L6 pseudogene 6 Neighboring gene acyl-CoA dehydrogenase long chain Neighboring gene myosin light chain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ23861

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone acetyltransferase activity (H4-K16 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone acetyltransferase activity (H4-K5 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone acetyltransferase activity (H4-K8 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
histone H4-K16 acetylation IEA
Inferred from Electronic Annotation
more info
 
histone H4-K5 acetylation IEA
Inferred from Electronic Annotation
more info
 
histone H4-K8 acetylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
KAT8 regulatory NSL complex subunit 1-like protein
Names
male-specific lethal 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307976.2NP_001294905.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 2

    See identical proteins and their annotated locations for NP_001294905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AA252480, AA404520, AC006994, AI289109, AK308432, BC143914, BU568066, DR002867
    Consensus CDS
    CCDS77519.1
    UniProtKB/Swiss-Prot
    A0AUZ9
    Related
    ENSP00000405724.1, ENST00000418791.5
    Conserved Domains (1) summary
    pfam15275
    Location:754873
    PEHE; PEHE domain
  2. NM_152519.4NP_689732.2  KAT8 regulatory NSL complex subunit 1-like protein isoform 1

    See identical proteins and their annotated locations for NP_689732.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006994, AI289109, AK074441, AL133053, BC032837, BQ948513, BU568066, CA393360, DR002867
    Consensus CDS
    CCDS33370.1
    UniProtKB/Swiss-Prot
    A0AUZ9
    Related
    ENSP00000281772.8, ENST00000281772.14
    Conserved Domains (1) summary
    pfam15275
    Location:796915
    PEHE; PEHE domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    210021421..210171409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246330.4XP_005246387.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X2

    See identical proteins and their annotated locations for XP_005246387.1

    UniProtKB/Swiss-Prot
    A0AUZ9
    Conserved Domains (1) summary
    pfam15275
    Location:796915
    PEHE; PEHE domain
  2. XM_005246332.5XP_005246389.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

    Conserved Domains (1) summary
    pfam15275
    Location:787906
    PEHE; PEHE domain
  3. XM_005246328.4XP_005246385.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

    Conserved Domains (1) summary
    pfam15275
    Location:829948
    PEHE; PEHE domain
  4. XM_011510707.3XP_011509009.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X2

    See identical proteins and their annotated locations for XP_011509009.1

    UniProtKB/Swiss-Prot
    A0AUZ9
    Conserved Domains (1) summary
    pfam15275
    Location:796915
    PEHE; PEHE domain
  5. XM_005246329.4XP_005246386.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X2

    See identical proteins and their annotated locations for XP_005246386.1

    UniProtKB/Swiss-Prot
    A0AUZ9
    Conserved Domains (1) summary
    pfam15275
    Location:796915
    PEHE; PEHE domain
  6. XM_017003430.1XP_016858919.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X2

    UniProtKB/Swiss-Prot
    A0AUZ9
    Conserved Domains (1) summary
    pfam15275
    Location:796915
    PEHE; PEHE domain
  7. XM_011510710.2XP_011509012.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X6

    Conserved Domains (1) summary
    pfam15275
    Location:368487
    PEHE; PEHE domain
  8. XM_017003431.1XP_016858920.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X8

  9. XM_011510706.3XP_011509008.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X2

    See identical proteins and their annotated locations for XP_011509008.1

    UniProtKB/Swiss-Prot
    A0AUZ9
    Conserved Domains (1) summary
    pfam15275
    Location:796915
    PEHE; PEHE domain
  10. XM_011510709.2XP_011509011.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X4

  11. XM_006712320.3XP_006712383.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X5

  12. XM_005246334.5XP_005246391.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X7

RNA

  1. XR_001738645.2 RNA Sequence

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