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SEPTIN10 septin 10 [ Homo sapiens (human) ]

Gene ID: 151011, updated on 5-Apr-2020

Summary

Official Symbol
SEPTIN10provided by HGNC
Official Full Name
septin 10provided by HGNC
Primary source
HGNC:HGNC:14349
See related
Ensembl:ENSG00000186522 MIM:611737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEPT10
Summary
This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in esophagus (RPKM 22.6), testis (RPKM 22.2) and 24 other tissues See more
Orthologs

Genomic context

See SEPTIN10 in Genome Data Viewer
Location:
2q13
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (109542797..109614205, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (110300372..110371783, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 3 Neighboring gene uncharacterized LOC107985773 Neighboring gene microRNA 4266 Neighboring gene Sharpr-MPRA regulatory region 2497 Neighboring gene ribosomal protein L37 pseudogene 12 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene BMS1 pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell division site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
septin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
septin ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321496.2NP_001308425.1  septin-10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    UniProtKB/TrEMBL
    B7Z371, Q59H84
    Conserved Domains (1) summary
    cd01850
    Location:6198
    CDC_Septin; CDC/Septin GTPase family
  2. NM_001321498.2NP_001308427.1  septin-10 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    Consensus CDS
    CCDS82497.1
    UniProtKB/Swiss-Prot
    Q9P0V9
    UniProtKB/TrEMBL
    B5ME97, Q59H84
    Related
    ENSP00000349116.4, ENST00000356688.8
    Conserved Domains (2) summary
    cd01850
    Location:63331
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:44397
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  3. NM_001321499.2NP_001308428.1  septin-10 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    UniProtKB/TrEMBL
    B7Z277, Q59H84
    Conserved Domains (1) summary
    cl21455
    Location:32164
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001321500.2NP_001308429.1  septin-10 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (2) summary
    cd01850
    Location:40308
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:21374
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  5. NM_001321501.2NP_001308430.1  septin-10 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (2) summary
    cd01850
    Location:21289
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:2355
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  6. NM_001321502.2NP_001308431.1  septin-10 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (1) summary
    cd01850
    Location:40308
    CDC_Septin; CDC/Septin GTPase family
  7. NM_001321503.2NP_001308432.1  septin-10 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (1) summary
    cl21455
    Location:10141
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. NM_001321504.2NP_001308433.1  septin-10 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (1) summary
    cl21455
    Location:1138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. NM_001321505.2NP_001308434.1  septin-10 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    UniProtKB/TrEMBL
    Q9H9P7
    Conserved Domains (1) summary
    cl21455
    Location:1138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. NM_001321506.2NP_001308435.1  septin-10 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (1) summary
    cl21455
    Location:10141
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  11. NM_001321507.2NP_001308436.1  septin-10 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (1) summary
    cd01850
    Location:6198
    CDC_Septin; CDC/Septin GTPase family
  12. NM_001321508.2NP_001308437.1  septin-10 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (1) summary
    cl21455
    Location:1138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  13. NM_001321509.2NP_001308438.1  septin-10 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (2) summary
    cd01850
    Location:21289
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:2355
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  14. NM_001321510.2NP_001308439.1  septin-10 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (1) summary
    cl21455
    Location:32164
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  15. NM_001321511.2NP_001308440.1  septin-10 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    UniProtKB/Swiss-Prot
    Q9P0V9
    Conserved Domains (1) summary
    cl21455
    Location:10141
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  16. NM_001321512.2NP_001308441.1  septin-10 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    Consensus CDS
    CCDS82496.1
    UniProtKB/Swiss-Prot
    Q9P0V9
    UniProtKB/TrEMBL
    E7EW69
    Related
    ENSP00000396728.1, ENST00000415095.5
    Conserved Domains (2) summary
    cd01850
    Location:63331
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:44397
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  17. NM_001321513.2NP_001308442.1  septin-10 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    Conserved Domains (2) summary
    cd01850
    Location:54322
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:35388
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  18. NM_001321514.2NP_001308443.1  septin-10 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    Conserved Domains (2) summary
    cd01850
    Location:48316
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:29382
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  19. NM_001321515.2NP_001308444.1  septin-10 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC011753, AC140485
    Conserved Domains (2) summary
    cd01850
    Location:31299
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:12365
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  20. NM_144710.5NP_653311.1  septin-10 isoform 1

    See identical proteins and their annotated locations for NP_653311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC011753, AC140485
    Consensus CDS
    CCDS46383.1
    UniProtKB/Swiss-Prot
    Q9P0V9
    UniProtKB/TrEMBL
    Q59H84
    Related
    ENSP00000380824.2, ENST00000397712.7
    Conserved Domains (1) summary
    cd01850
    Location:63331
    CDC_Septin; CDC/Septin GTPase family
  21. NM_178584.4NP_848699.1  septin-10 isoform 2

    See identical proteins and their annotated locations for NP_848699.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. Isoform 2 is shorter than isoform 1.
    Source sequence(s)
    AC011753, AC140485
    Consensus CDS
    CCDS42726.1
    UniProtKB/Swiss-Prot
    Q9P0V9
    UniProtKB/TrEMBL
    Q59H84
    Related
    ENSP00000380826.2, ENST00000397714.6
    Conserved Domains (2) summary
    cd01850
    Location:40308
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:21374
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    109542797..109614205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510702.2XP_011509004.1  septin-10 isoform X7

    Conserved Domains (1) summary
    cl21455
    Location:32164
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011510700.2XP_011509002.1  septin-10 isoform X4

    Conserved Domains (2) summary
    cd01850
    Location:21289
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:2355
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  3. XM_011510701.3XP_011509003.1  septin-10 isoform X6

    Conserved Domains (1) summary
    cd01850
    Location:6198
    CDC_Septin; CDC/Septin GTPase family
  4. XM_011510699.2XP_011509001.1  septin-10 isoform X3

    Conserved Domains (2) summary
    cd01850
    Location:40308
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:21374
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  5. XM_011510698.2XP_011509000.1  septin-10 isoform X2

    Conserved Domains (2) summary
    cd01850
    Location:48316
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:29382
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  6. XM_011510703.2XP_011509005.1  septin-10 isoform X1

    Conserved Domains (2) summary
    cd01850
    Location:54322
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:35388
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  7. XM_011510704.3XP_011509006.1  septin-10 isoform X8

    See identical proteins and their annotated locations for XP_011509006.1

    Conserved Domains (1) summary
    cd01850
    Location:63331
    CDC_Septin; CDC/Septin GTPase family
  8. XM_006712317.2XP_006712380.1  septin-10 isoform X5

    Related
    ENSP00000407790.1, ENST00000437928.5
    Conserved Domains (2) summary
    cd01850
    Location:63331
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:44397
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RNA

  1. XR_922870.3 RNA Sequence

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