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GAREM2 GRB2 associated regulator of MAPK1 subtype 2 [ Homo sapiens (human) ]

Gene ID: 150946, updated on 11-Jun-2021

Summary

Official Symbol
GAREM2provided by HGNC
Official Full Name
GRB2 associated regulator of MAPK1 subtype 2provided by HGNC
Primary source
HGNC:HGNC:27172
See related
Ensembl:ENSG00000157833 MIM:617999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM59B; GAREML
Expression
Broad expression in brain (RPKM 5.7), testis (RPKM 1.0) and 17 other tissues See more
Orthologs
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Genomic context

See GAREM2 in Genome Data Viewer
Location:
2p23.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (26173088..26202529)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26395957..26412532)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene 6 Neighboring gene peptidylprolyl isomerase like 1 pseudogene 1 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene uncharacterized LOC105374334 Neighboring gene adhesion G protein-coupled receptor F3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00375, KIAA2038

General protein information

Preferred Names
GRB2-associated and regulator of MAPK protein 2
Names
GRB2 associated regulator of MAPK1 2
GRB2 associated, regulator of MAPK1-like
GRB2-associated and regulator of MAPK protein-like
GRB2-associated and regulator of MAPK1-like
family with sequence similarity 59, member B
protein FAM59B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168241.2NP_001161713.1  GRB2-associated and regulator of MAPK protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001161713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AA736392, AB124552, AC011742, CX759737
    Consensus CDS
    CCDS54336.1
    UniProtKB/Swiss-Prot
    Q75VX8
    Related
    ENSP00000384593.1, ENST00000401533.7
    Conserved Domains (2) summary
    cd09525
    Location:806872
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:29341
    CABIT; Cell-cycle sustaining, positive selection,
  2. NM_001191033.2NP_001177962.1  GRB2-associated and regulator of MAPK protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA736392, AB015349, AC011742, AK090454
    Consensus CDS
    CCDS54337.1
    UniProtKB/Swiss-Prot
    Q75VX8
    Related
    ENSP00000384581.1, ENST00000407684.1
    Conserved Domains (2) summary
    cd09525
    Location:596662
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:7264
    CABIT; Cell-cycle sustaining, positive selection,

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    26173088..26202529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532567.3XP_011530869.1  GRB2-associated and regulator of MAPK protein 2 isoform X4

    Conserved Domains (1) summary
    pfam12736
    Location:29341
    CABIT; Cell-cycle sustaining, positive selection,
  2. XM_006711951.4XP_006712014.1  GRB2-associated and regulator of MAPK protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q75VX8
    Conserved Domains (2) summary
    cd09525
    Location:673739
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:29341
    CABIT; Cell-cycle sustaining, positive selection,
  3. XM_011532565.3XP_011530867.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530867.1

    Conserved Domains (2) summary
    cd09525
    Location:804870
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:36339
    CABIT; Cell-cycle sustaining, positive selection,
  4. XM_011532564.2XP_011530866.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530866.1

    Conserved Domains (2) summary
    cd09525
    Location:804870
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:36339
    CABIT; Cell-cycle sustaining, positive selection,
  5. XM_011532566.2XP_011530868.1  GRB2-associated and regulator of MAPK protein 2 isoform X2

    Conserved Domains (2) summary
    cd09525
    Location:687753
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:1222
    CABIT; Cell-cycle sustaining, positive selection,
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