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TCF23 transcription factor 23 [ Homo sapiens (human) ]

Gene ID: 150921, updated on 11-Jun-2021

Summary

Official Symbol
TCF23provided by HGNC
Official Full Name
transcription factor 23provided by HGNC
Primary source
HGNC:HGNC:18602
See related
Ensembl:ENSG00000163792 MIM:609635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OUT; TCF-23; bHLHa24
Summary
The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010]
Expression
Biased expression in endometrium (RPKM 12.5), ovary (RPKM 9.5) and 2 other tissues See more
Orthologs
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Genomic context

See TCF23 in Genome Data Viewer
Location:
2p23.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27148892..27156974)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27371872..27379842)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding Neighboring gene proline rich 30 Neighboring gene solute carrier family 5 member 6 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in developmental process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in euchromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor 23
Names
class A basic helix-loop-helix protein 24
class II basic helix-loop-helix protein TCF23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175769.3NP_786951.1  transcription factor 23

    See identical proteins and their annotated locations for NP_786951.1

    Status: REVIEWED

    Source sequence(s)
    AC013403, BC137191
    Consensus CDS
    CCDS33163.1
    UniProtKB/Swiss-Prot
    Q7RTU1
    Related
    ENSP00000296096.5, ENST00000296096.6
    Conserved Domains (1) summary
    smart00353
    Location:83132
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27148892..27156974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264159.5XP_005264216.1  transcription factor 23 isoform X1

    Conserved Domains (1) summary
    smart00353
    Location:83132
    HLH; helix loop helix domain
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