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FBXO41 F-box protein 41 [ Homo sapiens (human) ]

Gene ID: 150726, updated on 5-Aug-2018

Summary

Official Symbol
FBXO41provided by HGNC
Official Full Name
F-box protein 41provided by HGNC
Primary source
HGNC:HGNC:29409
See related
Ensembl:ENSG00000163013 MIM:609108; Vega:OTTHUMG00000164127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX41
Summary
This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]
Expression
Biased expression in brain (RPKM 10.6), lymph node (RPKM 3.0) and 13 other tissues See more
Orthologs

Genomic context

See FBXO41 in Genome Data Viewer
Location:
2p13.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (73254682..73284449, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73481810..73496758, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protease associated domain containing 1 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene early growth response 4 Neighboring gene RNA, U6 small nuclear 111, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37709

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033973.1 RefSeqGene

    Range
    5001..19949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080410.2NP_001073879.2  F-box only protein 41

    See identical proteins and their annotated locations for NP_001073879.2

    Status: REVIEWED

    Source sequence(s)
    AB075820, AC010913, AK055121, BC112202, R45456
    Consensus CDS
    CCDS46337.2
    UniProtKB/Swiss-Prot
    Q8TF61
    Related
    ENSP00000295133.6, ENST00000295133.9
    Conserved Domains (5) summary
    TIGR02473
    Location:218350
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:1033
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557595
    F-box-like; F-box-like
    pfam16515
    Location:239301
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    73254682..73284449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003421.2XP_016858910.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    Q8TF61
    Conserved Domains (5) summary
    TIGR02473
    Location:218350
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:1033
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557595
    F-box-like; F-box-like
    pfam16515
    Location:239301
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  2. XM_011532562.2XP_011530864.1  F-box only protein 41 isoform X1

    See identical proteins and their annotated locations for XP_011530864.1

    UniProtKB/Swiss-Prot
    Q8TF61
    Related
    ENSP00000430968.2, OTTHUMP00000272140, ENST00000520530.2
    Conserved Domains (5) summary
    TIGR02473
    Location:218350
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:1033
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557595
    F-box-like; F-box-like
    pfam16515
    Location:239301
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  3. XM_006711950.3XP_006712013.1  F-box only protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006712013.1

    UniProtKB/Swiss-Prot
    Q8TF61
    Conserved Domains (5) summary
    TIGR02473
    Location:218350
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:1033
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557595
    F-box-like; F-box-like
    pfam16515
    Location:239301
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  4. XM_017003423.2XP_016858912.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    Q8TF61
    Conserved Domains (5) summary
    TIGR02473
    Location:218350
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:1033
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557595
    F-box-like; F-box-like
    pfam16515
    Location:239301
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  5. XM_017003422.2XP_016858911.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    Q8TF61
    Conserved Domains (5) summary
    TIGR02473
    Location:218350
    flagell_FliJ; flagellar export protein FliJ
    sd00017
    Location:1033
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557595
    F-box-like; F-box-like
    pfam16515
    Location:239301
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  6. XM_005264158.3XP_005264215.1  F-box only protein 41 isoform X3

    Conserved Domains (2) summary
    sd00034
    Location:265291
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:163201
    F-box-like; F-box-like
  7. XM_011532563.2XP_011530865.1  F-box only protein 41 isoform X2

    Conserved Domains (2) summary
    sd00034
    Location:411437
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:309347
    F-box-like; F-box-like
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