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FBXO41 F-box protein 41 [ Homo sapiens (human) ]

Gene ID: 150726, updated on 26-Sep-2020

Summary

Official Symbol
FBXO41provided by HGNC
Official Full Name
F-box protein 41provided by HGNC
Primary source
HGNC:HGNC:29409
See related
Ensembl:ENSG00000163013 MIM:609108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX41
Summary
This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]
Expression
Biased expression in brain (RPKM 10.6), lymph node (RPKM 3.0) and 13 other tissues See more
Orthologs

Genomic context

See FBXO41 in Genome Data Viewer
Location:
2p13.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (73254690..73284478, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73481810..73496758, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protease associated domain containing 1 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene early growth response 4 Neighboring gene RNA, U6 small nuclear 111, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37709

Gene Ontology Provided by GOA

Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033973.1 RefSeqGene

    Range
    5001..19949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080410.4NP_001073879.2  F-box only protein 41

    See identical proteins and their annotated locations for NP_001073879.2

    Status: REVIEWED

    Source sequence(s)
    AC010913
    Consensus CDS
    CCDS46337.2
    UniProtKB/Swiss-Prot
    Q8TF61
    Conserved Domains (4) summary
    PHA03307
    Location:347557
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:199346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557592
    F-box-like
  2. NM_001371389.2NP_001358318.1  F-box only protein 41

    Status: REVIEWED

    Source sequence(s)
    AC010913
    Related
    ENSP00000430968.2, ENST00000520530.2
    Conserved Domains (4) summary
    PHA03307
    Location:347557
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:199346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557592
    F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    73254690..73284478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003421.2XP_016858910.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    Q8TF61
    Conserved Domains (4) summary
    PHA03307
    Location:347557
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:199346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557592
    F-box-like
  2. XM_017003423.2XP_016858912.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    Q8TF61
    Conserved Domains (4) summary
    PHA03307
    Location:347557
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:199346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557592
    F-box-like
  3. XM_017003422.2XP_016858911.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    Q8TF61
    Conserved Domains (4) summary
    PHA03307
    Location:347557
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:199346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00034
    Location:659685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557592
    F-box-like
  4. XM_005264158.3XP_005264215.1  F-box only protein 41 isoform X3

    Conserved Domains (2) summary
    sd00034
    Location:265291
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:163201
    F-box-like; F-box-like
  5. XM_011532563.2XP_011530865.1  F-box only protein 41 isoform X2

    Conserved Domains (2) summary
    sd00034
    Location:411437
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:309347
    F-box-like; F-box-like
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