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H2-T23 histocompatibility 2, T region locus 23 [ Mus musculus (house mouse) ]

Gene ID: 15040, updated on 26-Jun-2024

Summary

Official Symbol
H2-T23provided by MGI
Official Full Name
histocompatibility 2, T region locus 23provided by MGI
Primary source
MGI:MGI:95957
See related
Ensembl:ENSMUSG00000067212 AllianceGenome:MGI:95957
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
37b; 37c; Qa1; Qa-1; T18c; T23b; T23d; H2-K1; Qed-1; H-2T23; H2-Qa1; Qa-1(b); T18c(37)
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; inner ear development; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 290.8), large intestine adult (RPKM 270.0) and 18 other tissues See more
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Genomic context

See H2-T23 in Genome Data Viewer
Location:
17 B1; 17 18.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36340869..36343593, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36029977..36032701, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene proline-rich polypeptide 3 Neighboring gene guanine nucleotide binding protein-like 1 Neighboring gene RIKEN cDNA A930015D03 gene Neighboring gene STARR-positive B cell enhancer ABC_E5609 Neighboring gene STARR-positive B cell enhancer ABC_E8921 Neighboring gene STARR-positive B cell enhancer ABC_E959 Neighboring gene STARR-positive B cell enhancer ABC_E4214 Neighboring gene STARR-positive B cell enhancer ABC_E5610 Neighboring gene STARR-positive B cell enhancer ABC_E9951 Neighboring gene histocompatibility 2, T region locus 24 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36157683-36157870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36160698-36160881 Neighboring gene STARR-positive B cell enhancer ABC_E8675 Neighboring gene STARR-positive B cell enhancer ABC_E168 Neighboring gene histocompatibility 2, T region locus 22 Neighboring gene predicted gene 6034 Neighboring gene predicted gene, 54001

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117681

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lumenal side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
H-2 class I histocompatibility antigen, D-37 alpha chain
Names
MHC class I antigen Qa1
MHC class II antigen K
MHC classIb Qa1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010398.3NP_034528.1  H-2 class I histocompatibility antigen, D-37 alpha chain precursor

    See identical proteins and their annotated locations for NP_034528.1

    Status: PROVISIONAL

    Source sequence(s)
    AC112970
    Consensus CDS
    CCDS28715.1
    UniProtKB/Swiss-Prot
    P06339
    UniProtKB/TrEMBL
    O98032, Q3V014
    Related
    ENSMUSP00000099739.5, ENSMUST00000102678.5
    Conserved Domains (3) summary
    cd07698
    Location:203295
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cd12087
    Location:296333
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00129
    Location:22199
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36340869..36343593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)