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PHETA2 PH domain containing endocytic trafficking adaptor 2 [ Homo sapiens (human) ]

Gene ID: 150368, updated on 5-Aug-2018

Summary

Official Symbol
PHETA2provided by HGNC
Official Full Name
PH domain containing endocytic trafficking adaptor 2provided by HGNC
Primary source
HGNC:HGNC:27161
See related
Ensembl:ENSG00000177096 MIM:614240; Vega:OTTHUMG00000151285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ses2; FAM109B; IPIP27B
Expression
Ubiquitous expression in placenta (RPKM 8.4), urinary bladder (RPKM 5.1) and 24 other tissues See more
Orthologs

Genomic context

See PHETA2 in Genome Data Viewer
Location:
22q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (42074244..42079438)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42470255..42475445)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene WBP2 N-terminal like Neighboring gene CYP2D6 downstream enhancer Neighboring gene uncharacterized LOC107985551 Neighboring gene alpha-N-acetylgalactosaminidase Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 1 Neighboring gene single-pass membrane protein with aspartate rich tail 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene NDUFA6 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125831, MGC125832, DKFZp686J07229

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sesquipedalian-2
Names
27 kDa inositol polyphosphate phosphatase interacting protein B
family with sequence similarity 109 member B
inositol polyphosphate phosphatase-interacting protein B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002034.2NP_001002034.2  sesquipedalian-2

    See identical proteins and their annotated locations for NP_001002034.2

    Status: VALIDATED

    Source sequence(s)
    BX648402, Z82192
    Consensus CDS
    CCDS33655.1
    UniProtKB/Swiss-Prot
    Q6ICB4
    Related
    ENSP00000312753.3, OTTHUMP00000199675, ENST00000321753.7, OTTHUMT00000322084
    Conserved Domains (1) summary
    cl17171
    Location:11138
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    42074244..42079438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261373.3XP_005261430.1  sesquipedalian-2 isoform X1

    See identical proteins and their annotated locations for XP_005261430.1

    UniProtKB/Swiss-Prot
    Q6ICB4
    Conserved Domains (1) summary
    cl17171
    Location:11138
    PH-like; Pleckstrin homology-like domain

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003315971.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1..1783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NW_004504305.1 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    1..1783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NT_187682.1 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    1..1783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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