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CHADL chondroadherin like [ Homo sapiens (human) ]

Gene ID: 150356, updated on 12-Aug-2018

Summary

Official Symbol
CHADLprovided by HGNC
Official Full Name
chondroadherin likeprovided by HGNC
Primary source
HGNC:HGNC:25165
See related
Ensembl:ENSG00000100399 MIM:616236; Vega:OTTHUMG00000150936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLRR4B
Expression
Ubiquitous expression in brain (RPKM 3.6), prostate (RPKM 1.4) and 25 other tissues See more
Orthologs

Genomic context

See CHADL in Genome Data Viewer
Location:
22q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (41229510..41241771, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41605861..41636935, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene EP300 antisense RNA 1 Neighboring gene leucine rich repeat containing 37 member A14, pseudogene Neighboring gene uncharacterized LOC646927 Neighboring gene uncharacterized LOC100506544 Neighboring gene L3MBTL2, polycomb repressive complex 1 subunit Neighboring gene Ran GTPase activating protein 1 Neighboring gene microRNA 6889 Neighboring gene zinc finger CCCH-type containing 7B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chondroadherin-like (CHADL) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
collagen fibril binding IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix structural constituent conferring compression resistance ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
negative regulation of chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of collagen fibril organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
chondroadherin-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138481.1NP_612490.1  chondroadherin-like protein precursor

    See identical proteins and their annotated locations for NP_612490.1

    Status: VALIDATED

    Source sequence(s)
    AL035681
    Consensus CDS
    CCDS46715.1
    UniProtKB/Swiss-Prot
    Q6NUI6
    Related
    ENSP00000216241.9, OTTHUMP00000198751, ENST00000216241.13, OTTHUMT00000320597
    Conserved Domains (6) summary
    smart00013
    Location:395429
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:675723
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:424603
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:427450
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:643676
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:160218
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    41229510..41241771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529933.2XP_011528235.1  chondroadherin-like protein isoform X1

    Conserved Domains (6) summary
    smart00013
    Location:463497
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:743791
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:492671
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:495518
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:711744
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:228286
    LRR_8; Leucine rich repeat
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