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DUSP18 dual specificity phosphatase 18 [ Homo sapiens (human) ]

Gene ID: 150290, updated on 8-Dec-2018

Summary

Official Symbol
DUSP18provided by HGNC
Official Full Name
dual specificity phosphatase 18provided by HGNC
Primary source
HGNC:HGNC:18484
See related
Ensembl:ENSG00000167065 MIM:611446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSP18; DUSP20; LMWDSP20
Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression
Broad expression in testis (RPKM 4.3), lung (RPKM 2.8) and 24 other tissues See more
Orthologs

Genomic context

See DUSP18 in Genome Data Viewer
Location:
22q12.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (30652051..30667890, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31058039..31063874, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene pescadillo ribosomal biogenesis factor 1 Neighboring gene transcobalamin 2 Neighboring gene solute carrier family 35 member E4 Neighboring gene ribosomal protein L13a pseudogene 26 Neighboring gene oxysterol binding protein 2 Neighboring gene microRNA 3200 Neighboring gene OSBP2 intron CAGE-defined high expression enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC32658

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
inactivation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 18
Names
low molecular weight dual specificity phosphatase 20
NP_001291723.1
NP_001291724.1
NP_001291725.1
NP_689724.3
XP_005261425.1
XP_006724211.1
XP_011528222.1
XP_011528223.1
XP_016884116.1
XP_016884117.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304794.1NP_001291723.1  dual specificity protein phosphatase 18 isoform a

    See identical proteins and their annotated locations for NP_001291723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AC003072, BM550612, DA378760
    Consensus CDS
    CCDS13883.1
    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Related
    ENSP00000340795.4, ENST00000342474.4
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. NM_001304795.1NP_001291724.1  dual specificity protein phosphatase 18 isoform a

    See identical proteins and their annotated locations for NP_001291724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    BC030987, DA378760
    Consensus CDS
    CCDS13883.1
    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Related
    ENSP00000385463.1, ENST00000404885.5
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  3. NM_001304796.1NP_001291725.1  dual specificity protein phosphatase 18 isoform b

    See identical proteins and their annotated locations for NP_001291725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a segment of the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC003072, BC028724, DA378760
    Consensus CDS
    CCDS77667.1
    UniProtKB/TrEMBL
    F2Z2P2
    Related
    ENSP00000384946.1, ENST00000403268.1
    Conserved Domains (1) summary
    cl21483
    Location:1953
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_152511.4NP_689724.3  dual specificity protein phosphatase 18 isoform a

    See identical proteins and their annotated locations for NP_689724.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AC003072, AK056074, DA378760
    Consensus CDS
    CCDS13883.1
    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Related
    ENSP00000333917.3, ENST00000334679.3
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    30652051..30667890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028628.1XP_016884117.1  dual specificity protein phosphatase 18 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. XM_017028627.2XP_016884116.1  dual specificity protein phosphatase 18 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  3. XM_005261368.5XP_005261425.1  dual specificity protein phosphatase 18 isoform X1

    See identical proteins and their annotated locations for XP_005261425.1

    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  4. XM_006724148.4XP_006724211.1  dual specificity protein phosphatase 18 isoform X1

    See identical proteins and their annotated locations for XP_006724211.1

    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  5. XM_011529921.3XP_011528223.1  dual specificity protein phosphatase 18 isoform X1

    See identical proteins and their annotated locations for XP_011528223.1

    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  6. XM_011529920.3XP_011528222.1  dual specificity protein phosphatase 18 isoform X1

    See identical proteins and their annotated locations for XP_011528222.1

    UniProtKB/Swiss-Prot
    Q8NEJ0
    UniProtKB/TrEMBL
    A0A024R1L2
    Conserved Domains (1) summary
    cd00127
    Location:19155
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RNA

  1. XR_001755171.2 RNA Sequence

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