U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H2-T10 histocompatibility 2, T region locus 10 [ Mus musculus (house mouse) ]

Gene ID: 15024, updated on 26-Sep-2022

Summary

Go to the top of the page Help
Official Symbol
H2-T10provided by MGI
Official Full Name
histocompatibility 2, T region locus 10provided by MGI
Primary source
MGI:MGI:95942
See related
Ensembl:ENSMUSG00000079491 AllianceGenome:MGI:95942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2T10
Summary
Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; lung; and musculoskeletal system. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Broad expression in thymus adult (RPKM 27.5), spleen adult (RPKM 12.0) and 15 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See H2-T10 in Genome Data Viewer
Location:
17 B1; 17 18.93 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36426763..36432336, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36115871..36121444, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54002 Neighboring gene histocompatibility 2, T region locus, pseudogene Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene 7030 Neighboring gene histocompatibility 2, T region pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule. Crowley MP, et al. Science, 2000 Jan 14. PMID 10634788
  2. The nature of major histocompatibility complex recognition by gamma delta T cells. Schild H, et al. Cell, 1994 Jan 14. PMID 8287478
  3. Role of a selecting ligand in shaping the murine γδ-TCR repertoire. Fahl SP, et al. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432160, Free PMC Article
  4. Functions of nonclassical MHC and non-MHC-encoded class I molecules. Braud VM, et al. Curr Opin Immunol, 1999 Feb. PMID 10047540
  5. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Ito K, et al. Cell, 1990 Aug 10. PMID 2379238

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
histocompatibility 2, T region locus 10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010395.7 → NP_034525.4  histocompatibility 2, T region locus 10 precursor

    See identical proteins and their annotated locations for NP_034525.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the coding allele found in NOD, 129, FVB/N, and other strains (PMID:2379238).
    Source sequence(s)
    AK088241, AK153876
    UniProtKB/TrEMBL
    Q8WLM9
    Conserved Domains (2) summary
    cd07698
    Location:193 → 285
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:27 → 189
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RNA

  1. NR_046286.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the non-coding allele found in C57BL/6 (PMID:2379238).
    Source sequence(s)
    CT030728
    Related
    ENSMUST00000174625.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36426763..36432336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials