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POLY polyprotein [ Yellow fever virus ]

Gene ID: 1502173, updated on 18-Aug-2023

Summary

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Gene symbol
POLY
Gene description
polyprotein
Locus tag
YFVgp1
Gene type
protein coding
RNA name
PP mRNA
RefSeq status
REVIEWED
Organism
Yellow fever virus (strain: 17D vaccine strain)
Lineage
Viruses; Riboviria; Flaviviridae; Flavivirus
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Genomic context

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Sequence:
NC_002031.1 (1..10862)

NC_002031.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002031.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a dominant endoplasmic reticulum-retention signal in yellow fever virus pre-membrane protein. Ciczora Y, et al. J Gen Virol, 2010 Feb. PMID 19846669
  2. Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Rice CM, et al. Science, 1985 Aug 23. PMID 4023707
  3. NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies. Amberg SM, et al. J Virol, 1994 Jun. PMID 8189517, Free PMC Article
  4. RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria. Warrener P, et al. J Virol, 1993 Feb. PMID 8380474, Free PMC Article
  5. Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing. Amberg SM, et al. J Virol, 1999 Oct. PMID 10482557, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus.
    Title: Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus.
  2. The structure of the full-length NS5 protein, a key enzyme for the replication of flaviviruses that contains both a methyltransferase domain and an RNA dependent RNA polymerase domain, at 3.1 A resolution.
    Title: Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses.
  3. Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.
    Title: Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.
  4. adaptive genetic diversification has occurred on viral nonstructural protein 5 in African and South American yellow fever virus populations
    Title: Adaptive Diversification Between Yellow Fever Virus West African and South American Lineages: A Genome-Wide Study.
  5. This suggests that DNAJC14's folding activity normally modulates yellow fever virus NS3/4A/2K cleavage events to liberate appropriate levels of NS3 and NS4A and promote replication complex formation.
    Title: Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication.
  6. These data support a complex interplay between yellow fever virus NS2A and NS3 in virion assembly and identify a basic cluster in the NS2A N terminus to be critical in this process.[NS2A, NS3]
    Title: A basic cluster in the N terminus of yellow fever virus NS2A contributes to infectious particle production.
  7. Binding of Yellow fever virus NS5 to the IFN-activated transcription factor STAT2 only in cells that have been stimulated with IFN-beta.
    Title: The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon.
  8. While the increase of the positive charge in the envelope protein domain III may reduce the virulence of YFV in mice, this mutation favored the establishment of the viral infection in Aedes aegypti.
    Title: Mutagenesis analysis of T380R mutation in the envelope protein of yellow fever virus.
  9. These results indicate an interaction of human eIF3L with yellow fever virus NS5 and that eIF3L overexpression facilitates translation, which has potential implications for virus replication.
    Title: The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.
  10. study shows that the yellow fever virus (YFV) NS5 protein is able to interact with U1A, a protein involved in splicing and polyadenylation; a region between amino acids 368 and 448 was identified as the site of interaction of the NS5 protein with U1A
    Title: The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
polyprotein
Names
core protein C
anchored core protein C
M protein precursor
matrix protein M
envelope protein
non-structural protein NS1
non-structural protein NS2a
non-structural protein NS2b
non-structural protein NS3
non-structural protein NS4a
2K protein
non-structural protein NS4b
RNA-dependent RNA polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002031.1 Reference assembly

    Range
    1..10862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_041726.1 polyprotein precursor [Yellow fever virus]

    See identical proteins and their annotated locations for NP_041726.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O42028, O91857, P03314, P19901, Q102J3, Q45RQ2, Q89275, Q89276, Q9W878, Q9YWN0, Q9YWN1, Q9YWN2
    UniProtKB/TrEMBL
    A0A2R4G6T0
    Conserved Domains (20) summary
    pfam01003
    Location:5 → 101
    Flavi_capsid; Flavivirus capsid protein C
    pfam01003
    Location:5 → 119
    Flavi_capsid; Flavivirus capsid protein C
    pfam01004
    Location:91 → 164
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:5 → 82
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam01004
    Location:2 → 75
    Flavi_M; Flavivirus envelope glycoprotein M
    TIGR04240
    Location:397 → 493
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00869
    Location:2 → 294
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam02832
    Location:296 → 391
    Flavi_glycop_C; Flavivirus glycoprotein, immunoglobulin-like domain
    pfam00948
    Location:2 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam01005
    Location:9 → 194
    Flavi_NS2A; Flavivirus non-structural protein NS2A
    pfam01002
    Location:4 → 130
    Flavi_NS2B; Flavivirus non-structural protein NS2B
    smart00487
    Location:184 → 330
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:366 → 478
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00949
    Location:21 → 170
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam07652
    Location:190 → 335
    Flavi_DEAD; Flavivirus DEAD domain
    pfam01350
    Location:4 → 126
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam01350
    Location:1 → 21
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam01349
    Location:1 → 244
    Flavi_NS4B; Flavivirus non-structural protein NS4B
    pfam00972
    Location:252 → 897
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    cd20761
    Location:8 → 237
    capping_2-OMTase_Flaviviridae; Cap-0 specific (nucleoside-2'-O-)-methyltransferase of flaviviridae
Nucleotide Protein
Heading Accession and Version

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