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RUBVgp2 structural polyprotein [ Rubella virus ]

Gene ID: 1502162, updated on 3-Dec-2024
Gene symbol
RUBVgp2
Gene description
structural polyprotein
Locus tag
RUBVgp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rubella virus (strain: F-Therien)
Lineage
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; Hepelivirales; Matonaviridae; Rubivirus; Rubivirus rubellae
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Location:
clone: pRUB1025
Sequence:
NC_001545.2 (6435..9762)

NC_001545.2Genomic Context describing neighboring genes Neighboring gene non-structural polyprotein

Genomic Sequence:
NC_001545.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Rubella virus: first calcium-requiring viral fusion protein. Dubé M, et al. PLoS Pathog, 2014 Dec. PMID 25474548, Free PMC Article
  2. R237 and h238 are key amino acids in the rubella virus E1 neutralization epitope. Li ZM, et al. Viral Immunol, 2014 Nov. PMID 25226223
  3. Functional and evolutionary insight from the crystal structure of rubella virus protein E1. DuBois RM, et al. Nature, 2013 Jan 24. PMID 23292515
  4. Rubella virus-like replicon particles: analysis of encapsidation determinants and non-structural roles of capsid protein in early post-entry replication. Claus C, et al. J Gen Virol, 2012 Mar. PMID 22113006, Free PMC Article
  5. Rubella virus pseudotypes and a cell-cell fusion assay as tools for functional analysis of the rubella virus E2 and E1 envelope glycoproteins. Claus C, et al. J Gen Virol, 2006 Oct. PMID 16963762

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data indicate that RuV E1 is the first example of a Ca(2+)-dependent viral fusion protein and has a unique membrane interaction mechanism.
    Title: Rubella virus: first calcium-requiring viral fusion protein.
  2. Thus, R237 and H238 are key amino acids in the rubella virus E1 neutralization epitope.
    Title: R237 and h238 are key amino acids in the rubella virus E1 neutralization epitope.
  3. A structural study based on the 1.8 A resolution crystal structure of envelope glycoprotein E1.
    Title: Functional and evolutionary insight from the crystal structure of rubella virus protein E1.
  4. Deletion of the N-terminal eight amino acids of the capsid protein reduced Rubella virus-like replicon particles titre significantly, which could be partially complemented by native capsid protein provided in trans.
    Title: Rubella virus-like replicon particles: analysis of encapsidation determinants and non-structural roles of capsid protein in early post-entry replication.
  5. The authors found that the human myelin oligodendrocyte glycoprotein (MOG) specifically bound to the E1 envelope glycoprotein of rubella virus, and an antibody against MOG could block rubella virus infection.
    Title: Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus.
  6. Downregulation of mitochondrial matrix protein p32 interferes with microtubule-directed redistribution of mitochondria in rubella virus -infected cells. However, the association of the viral C protein with mitochondria was not affected.
    Title: Involvement of p32 and microtubules in alteration of mitochondrial functions by rubella virus.
  7. An arginine-rich motif between aa 60 and 68 of the C protein was necessary for the rescue of DeltaNotI deletion mutants and substituted for an arginine-rich motif between aa 731 and 735 of the P150 protein when the C protein was introduced into P150.
    Title: Functional replacement of a domain in the rubella virus p150 replicase protein by the virus capsid protein.
  8. inhibits genetic translation by sequestration of host poly(a)-binding protein
    Title: Rubella virus capsid protein interacts with poly(a)-binding protein and inhibits translation.
  9. The entry functions of E1 and E2 glycoproteins of the Rubella virus were evaluated using viral pseudotypes and a cell-cell fusion assay.
    Title: Rubella virus pseudotypes and a cell-cell fusion assay as tools for functional analysis of the rubella virus E2 and E1 envelope glycoproteins.
Submit: New GeneRIF Correction
Preferred Names
structural polyprotein
Names
capsid protein
E2 envelope glycoprotein
E1 envelope glycoprotein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001545.2 Reference assembly

    Range
    6435..9762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_062884.1 structural polyprotein [Rubella virus]

    See identical proteins and their annotated locations for NP_062884.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P07566
    UniProtKB/TrEMBL
    C0JJB5
    Conserved Domains (3) summary
    pfam05750
    Location:1 → 300
    Rubella_Capsid; Rubella capsid protein
    pfam05749
    Location:1 → 267
    Rubella_E2; Rubella membrane glycoprotein E2
    pfam05748
    Location:1 → 481
    Rubella_E1; Rubella membrane glycoprotein E1
Nucleotide Protein
Heading Accession and Version

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