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SLC9B1 solute carrier family 9 member B1 [ Homo sapiens (human) ]

Gene ID: 150159, updated on 12-Aug-2018

Summary

Official Symbol
SLC9B1provided by HGNC
Official Full Name
solute carrier family 9 member B1provided by HGNC
Primary source
HGNC:HGNC:24244
See related
Ensembl:ENSG00000164037 MIM:611527; Vega:OTTHUMG00000161114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHA1; NHEDC1
Summary
The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Broad expression in testis (RPKM 16.0), kidney (RPKM 1.8) and 17 other tissues See more
Orthologs

Genomic context

See SLC9B1 in Genome Data Viewer
Location:
4q24
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (102885048..103019739, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (103806205..103947552, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723704 Neighboring gene ubiquitin conjugating enzyme E2 D3 Neighboring gene UBE2D3 antisense RNA 1 Neighboring gene RNA, U7 small nuclear 151 pseudogene Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene poly(A) binding protein cytoplasmic 1 pseudogene 7 Neighboring gene ACTR3B pseudogene 4 Neighboring gene solute carrier family 9 member B2 Neighboring gene 3-hydroxybutyrate dehydrogenase 2 Neighboring gene centromere protein E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 9, subfamily B (cation proton antiporter 2), member 1 (SLC9B1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC131641

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sodium:proton antiporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular pH ISS
Inferred from Sequence or Structural Similarity
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sperm principal piece ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sodium/hydrogen exchanger 9B1
Names
NHE domain-containing protein 1
Na(+)/H(+) exchanger-like domain-containing protein 1
sodium/hydrogen exchanger-like domain-containing protein 1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
solute carrier family 9, subfamily B (cation proton antiporter 2), member 1
testicular tissue protein Li 127

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008662.2 RefSeqGene

    Range
    5001..139692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001100874.2NP_001094344.1  sodium/hydrogen exchanger 9B1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC018797, AC097485, AF447585, AY461581, BC132712
    Consensus CDS
    CCDS47119.1
    UniProtKB/Swiss-Prot
    Q4ZJI4
    UniProtKB/TrEMBL
    A0A140VJQ1
    Related
    ENSP00000378269.3, OTTHUMP00000219742, ENST00000394789.7, OTTHUMT00000363842
    Conserved Domains (1) summary
    cl01133
    Location:140445
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  2. NM_139173.3NP_631912.2  sodium/hydrogen exchanger 9B1 isoform 1

    See identical proteins and their annotated locations for NP_631912.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC097485, DQ003059
    Consensus CDS
    CCDS34041.1
    UniProtKB/Swiss-Prot
    Q4ZJI4
    Related
    ENSP00000296422.7, OTTHUMP00000219741, ENST00000296422.11, OTTHUMT00000363841
    Conserved Domains (1) summary
    cl01133
    Location:140480
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RNA

  1. NR_047513.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018797, AC083826, AC097485, BC046636, DB526003
    Related
    ENST00000514972.5, OTTHUMT00000363845
  2. NR_047515.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018797, AC097485, BC022079
    Related
    ENST00000503584.5, OTTHUMT00000363844

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    102885048..103019739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714093.3XP_006714156.1  sodium/hydrogen exchanger 9B1 isoform X1

    See identical proteins and their annotated locations for XP_006714156.1

    UniProtKB/Swiss-Prot
    Q4ZJI4
    Conserved Domains (1) summary
    cl01133
    Location:140480
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  2. XM_011531622.2XP_011529924.1  sodium/hydrogen exchanger 9B1 isoform X1

    See identical proteins and their annotated locations for XP_011529924.1

    UniProtKB/Swiss-Prot
    Q4ZJI4
    Conserved Domains (1) summary
    cl01133
    Location:140480
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  3. XM_011531623.1XP_011529925.1  sodium/hydrogen exchanger 9B1 isoform X1

    See identical proteins and their annotated locations for XP_011529925.1

    UniProtKB/Swiss-Prot
    Q4ZJI4
    Conserved Domains (1) summary
    cl01133
    Location:140480
    Na_H_Exchanger; Sodium/hydrogen exchanger family
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