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IGSF5 immunoglobulin superfamily member 5 [ Homo sapiens (human) ]

Gene ID: 150084, updated on 1-Aug-2020

Summary

Official Symbol
IGSF5provided by HGNC
Official Full Name
immunoglobulin superfamily member 5provided by HGNC
Primary source
HGNC:HGNC:5952
See related
Ensembl:ENSG00000183067 MIM:610638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSF5; JAM4
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IGSF5 in Genome Data Viewer
Location:
21q22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (39632465..39802096)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (41117334..41174023)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene JCAD pseudogene 1 Neighboring gene B3GALT5 antisense RNA 1 Neighboring gene beta-1,3-galactosyltransferase 5 Neighboring gene B3GALT5 ERV-L LTR promoter Neighboring gene uncharacterized LOC107985499 Neighboring gene uncharacterized LOC107985500 Neighboring gene meiotic recombination hotspot PCP4-1 Neighboring gene meiotic recombination hotspot PCP4-2 Neighboring gene Purkinje cell protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
NHGRI GWA Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
NHGRI GWA Catalog
Genome-wide association study of suicide attempts in mood disorder patients.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • AF064860.5, AF064860.7

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
immunoglobulin superfamily member 5
Names
immunoglobulin superfamily 5 like
junctional adhesion molecule 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080444.1NP_001073913.1  immunoglobulin superfamily member 5

    See identical proteins and their annotated locations for NP_001073913.1

    Status: VALIDATED

    Source sequence(s)
    AF121782
    Consensus CDS
    CCDS33562.1
    UniProtKB/Swiss-Prot
    Q9NSI5
    Related
    ENSP00000369962.4, ENST00000380588.4
    Conserved Domains (2) summary
    smart00410
    Location:45138
    IG_like; Immunoglobulin like
    cl11960
    Location:110140
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    39632465..39802096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529472.2XP_011527774.1  immunoglobulin superfamily member 5 isoform X1

    Conserved Domains (2) summary
    smart00410
    Location:135228
    IG_like; Immunoglobulin like
    cl11960
    Location:236307
    Ig; Immunoglobulin domain
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