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PCC1 chromatin DNA-binding EKC/KEOPS complex subunit PCC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 1500489, updated on 6-Jul-2026
Official Symbol
PCC1
Official Full Name
chromatin DNA-binding EKC/KEOPS complex subunit PCC1
Primary source
SGD:S000028512
Locus tag
YKR095W-A
See related
AllianceGenome:SGD:S000028512; FungiDB:YKR095W-A; VEuPathDB:YKR095W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chromatin DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; tRNA threonylcarbamoyladenosine metabolic process; and telomere maintenance via recombination. Located in chromatin. Part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 2. Orthologous to human LAGE3 (L antigen family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PCC1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
2
Sequence:
Chromosome: XI; NC_001143.9 (625864..626205)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-60S ribosomal protein eL40 RPL40B fusion protein Neighboring gene Mlp1p Neighboring gene Esl2p Neighboring gene phosphoenolpyruvate carboxykinase PCK1

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Wan LC, et al. Nucleic Acids Res, 2016 Aug 19. PMID 27302132, Free PMC Article
  2. Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Zhang W, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25735745, Free PMC Article
  3. In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya. Perrochia L, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23258706, Free PMC Article
  4. Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Wan LC, et al. Nucleic Acids Res, 2013 Jul. PMID 23620299, Free PMC Article
  5. Yeast KEOPS complex regulates telomere length independently of its t(6)A modification function. Liu YY, et al. J Genet Genomics, 2018 May 20. PMID 29804714

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We found that Gon7 forms a stable heterodimer with Pcc1 and report the crystal structure of the Pcc1-Gon7 heterodimer.
    Title: Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex.
  2. EKC/KEOPS complex is specifically involved in the regulation of Bud9p localization downstream of Rax1p/Rax2p.
    Title: Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex.
  3. We have isolated a new yeast gene (PCC1) that codes for a factor homologous to human cancer-testis antigens.Pcc1p is a new transcription factor and that its mutation affects expression of several genes
    Title: Yeast homolog of a cancer-testis antigen defines a new transcription complex.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of translational fidelity NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA threonylcarbamoyladenosine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA threonylcarbamoyladenosine modification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in telomere maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of EKC/KEOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EKC/KEOPS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of EKC/KEOPS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
chromatin DNA-binding EKC/KEOPS complex subunit PCC1
NP_878113.4
  • Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p; ortholog of human LAGE3

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    625864..626205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184522.3 → NP_878113.4  chromatin DNA-binding EKC/KEOPS complex subunit PCC1

    See identical proteins and their annotated locations for NP_878113.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXF6, Q3E833
    UniProtKB/TrEMBL
    B3LRH0
    Conserved Domains (1) summary
    pfam09341
    Location:12 → 85
    Pcc1; Transcription factor Pcc1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E833.1

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