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LSM14B LSM family member 14B [ Homo sapiens (human) ]

Gene ID: 149986, updated on 3-May-2025
Official Symbol
LSM14Bprovided by HGNC
Official Full Name
LSM family member 14Bprovided by HGNC
Primary source
HGNC:HGNC:15887
See related
Ensembl:ENSG00000149657 MIM:620689; AllianceGenome:HGNC:15887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FT005; LSM13; FAM61B; RAP55B; C20orf40; bA11M20.3
Summary
Enables RNA binding activity. Predicted to be involved in several processes, including maternal mRNA clearance; meiotic cell cycle process involved in oocyte maturation; and ovarian follicle development. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in testis (RPKM 18.4), brain (RPKM 13.1) and 25 other tissues See more
Orthologs
mouse all
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See LSM14B in Genome Data Viewer
Location:
20q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62122475..62135374)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (63913343..63926242)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60697531..60710430)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60639656-60640169 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:60640170-60640684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13095 Neighboring gene uncharacterized LOC105372705 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:60641713-60642226 Neighboring gene microRNA 3195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60662279-60662835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60662836-60663391 Neighboring gene uncharacterized LOC105372706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60687696-60688502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:60697043-60697730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60697731-60698419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60698420-60699107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60708899-60709398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13101 Neighboring gene Sharpr-MPRA regulatory region 1753 Neighboring gene proteasome 20S subunit alpha 7 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:60735092-60736291 Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60736587-60737199

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation. Balak C, et al. Am J Hum Genet, 2019 Sep 5. PMID 31422817, Free PMC Article
  2. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. Albrecht M, et al. FEBS Lett, 2004 Jul 2. PMID 15225602
  3. An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry. Hecht M, et al. G3 (Bethesda), 2019 Jun 5. PMID 30975701, Free PMC Article
  4. The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes. Yamaki Y, et al. Mol Cell Biochem, 2016 Mar. PMID 26885983
  5. Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus. Zheng X, et al. Pathogens, 2021 Sep 8. PMID 34578187, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Replication interactions

Interaction Pubs
Knockdown of LSM14B, SCD6 homolog B by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25473, MGC61931

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in maternal mRNA clearance IEA
Inferred from Electronic Annotation
more info
  
involved_in maternal mRNA clearance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle process involved in oocyte maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle process involved in oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membraneless organelle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in membraneless organelle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ovarian follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein LSM14 homolog B
Names
LSM14 homolog B
LSM14B, SCD6 homolog B
RNA-associated protein 55B
family with sequence similarity 61, member B
hRAP55B

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144703.3 → NP_653304.2  protein LSM14 homolog B

    See identical proteins and their annotated locations for NP_653304.2

    Status: VALIDATED

    Source sequence(s)
    AL137077, BC035702, BM547301, BX370449, BX375905, CX166280, DB336439
    Consensus CDS
    CCDS46626.1
    UniProtKB/Swiss-Prot
    Q6PFW8, Q96LH8, Q9BX40
    Related
    ENSP00000279068.5, ENST00000279068.11
    Conserved Domains (2) summary
    cd01736
    Location:6 → 79
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:248 → 349
    FDF; FDF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62122475..62135374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528605.3 → XP_011526907.1  protein LSM14 homolog B isoform X1

    See identical proteins and their annotated locations for XP_011526907.1

    Conserved Domains (2) summary
    pfam09532
    Location:349 → 450
    FDF; FDF domain
    pfam12701
    Location:8 → 82
    LSM14; Scd6-like Sm domain

  2. XM_011528607.3 → XP_011526909.1  protein LSM14 homolog B isoform X3

    Conserved Domains (2) summary
    pfam09532
    Location:323 → 424
    FDF; FDF domain
    pfam12701
    Location:8 → 82
    LSM14; Scd6-like Sm domain

  3. XM_011528608.3 → XP_011526910.1  protein LSM14 homolog B isoform X4

    Conserved Domains (2) summary
    cd01736
    Location:6 → 79
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:313 → 414
    FDF; FDF domain

  4. XM_011528609.3 → XP_011526911.1  protein LSM14 homolog B isoform X6

    See identical proteins and their annotated locations for XP_011526911.1

    Conserved Domains (2) summary
    cd01736
    Location:6 → 79
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:274 → 375
    FDF; FDF domain

  5. XM_024451839.2 → XP_024307607.1  protein LSM14 homolog B isoform X7

    Conserved Domains (2) summary
    cd01736
    Location:6 → 79
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:248 → 349
    FDF; FDF domain

  6. XM_011528606.4 → XP_011526908.1  protein LSM14 homolog B isoform X2

    Conserved Domains (2) summary
    pfam09532
    Location:323 → 424
    FDF; FDF domain
    pfam12701
    Location:8 → 82
    LSM14; Scd6-like Sm domain

  7. XM_005260302.4 → XP_005260359.1  protein LSM14 homolog B isoform X5

    See identical proteins and their annotated locations for XP_005260359.1

    Conserved Domains (2) summary
    cd01736
    Location:6 → 79
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:287 → 388
    FDF; FDF domain

  8. XM_011528611.4 → XP_011526913.1  protein LSM14 homolog B isoform X9

    See identical proteins and their annotated locations for XP_011526913.1

    Conserved Domains (2) summary
    cd01736
    Location:6 → 79
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:222 → 323
    FDF; FDF domain

  9. XM_047439933.1 → XP_047295889.1  protein LSM14 homolog B isoform X8

  10. XM_024451841.2 → XP_024307609.1  protein LSM14 homolog B isoform X11

    Conserved Domains (1) summary
    pfam09532
    Location:203 → 304
    FDF; FDF domain

  11. XM_011528612.3 → XP_011526914.1  protein LSM14 homolog B isoform X10

    See identical proteins and their annotated locations for XP_011526914.1

    Conserved Domains (1) summary
    pfam09532
    Location:204 → 305
    FDF; FDF domain

  12. XM_047439934.1 → XP_047295890.1  protein LSM14 homolog B isoform X8

  13. XM_024451840.2 → XP_024307608.1  protein LSM14 homolog B isoform X10

    Conserved Domains (1) summary
    pfam09532
    Location:204 → 305
    FDF; FDF domain

  14. XM_011528613.3 → XP_011526915.1  protein LSM14 homolog B isoform X12

    See identical proteins and their annotated locations for XP_011526915.1

    UniProtKB/TrEMBL
    Q5TBP9
    Related
    ENSP00000355209.3, ENST00000361670.3
    Conserved Domains (1) summary
    pfam09532
    Location:168 → 269
    FDF; FDF domain

  15. XM_047439935.1 → XP_047295891.1  protein LSM14 homolog B isoform X13

RNA

  1. XR_936508.3 RNA Sequence

  2. XR_936509.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    63913343..63926242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323086.1 → XP_054179061.1  protein LSM14 homolog B isoform X1

  2. XM_054323088.1 → XP_054179063.1  protein LSM14 homolog B isoform X3

  3. XM_054323089.1 → XP_054179064.1  protein LSM14 homolog B isoform X4

  4. XM_054323091.1 → XP_054179066.1  protein LSM14 homolog B isoform X6

  5. XM_054323092.1 → XP_054179067.1  protein LSM14 homolog B isoform X7

  6. XM_054323087.1 → XP_054179062.1  protein LSM14 homolog B isoform X2

  7. XM_054323090.1 → XP_054179065.1  protein LSM14 homolog B isoform X5

  8. XM_054323093.1 → XP_054179068.1  protein LSM14 homolog B isoform X9

  9. XM_054323095.1 → XP_054179070.1  protein LSM14 homolog B isoform X10

  10. XM_054323097.1 → XP_054179072.1  protein LSM14 homolog B isoform X12

    UniProtKB/TrEMBL
    Q5TBP9

  11. XM_054323094.1 → XP_054179069.1  protein LSM14 homolog B isoform X10

  12. XM_054323096.1 → XP_054179071.1  protein LSM14 homolog B isoform X11

  13. XM_054323098.1 → XP_054179073.1  protein LSM14 homolog B isoform X13

RNA

  1. XR_008485239.1 RNA Sequence

  2. XR_008485240.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014054.1: Suppressed sequence

    Description
    NM_014054.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BX40.1 GenPept UniProtKB/Swiss-Prot:Q9BX40

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