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LSM14B LSM family member 14B [ Homo sapiens (human) ]

Gene ID: 149986, updated on 7-Jun-2020

Summary

Official Symbol
LSM14Bprovided by HGNC
Official Full Name
LSM family member 14Bprovided by HGNC
Primary source
HGNC:HGNC:15887
See related
Ensembl:ENSG00000149657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FT005; LSM13; FAM61B; RAP55B; C20orf40; bA11M20.3
Expression
Ubiquitous expression in testis (RPKM 18.4), brain (RPKM 13.1) and 25 other tissues See more
Orthologs

Genomic context

See LSM14B in Genome Data Viewer
Location:
20q13.33
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (62122454..62135378)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60697517..60710434)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 4 Neighboring gene uncharacterized LOC105372705 Neighboring gene microRNA 3195 Neighboring gene uncharacterized LOC105372706 Neighboring gene proteasome 20S subunit alpha 7 Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of LSM14B, SCD6 homolog B by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25473, MGC61931

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein LSM14 homolog B
Names
LSM14 homolog B
LSM14B, SCD6 homolog B
RNA-associated protein 55B
family with sequence similarity 61, member B
hRAP55B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144703.3NP_653304.2  protein LSM14 homolog B

    See identical proteins and their annotated locations for NP_653304.2

    Status: VALIDATED

    Source sequence(s)
    AL137077, BC035702, BM547301, BX370449, BX375905, CX166280, DB336439
    Consensus CDS
    CCDS46626.1
    UniProtKB/Swiss-Prot
    Q9BX40
    Related
    ENSP00000279068.5, ENST00000279068.11
    Conserved Domains (2) summary
    cd01736
    Location:679
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:248349
    FDF; FDF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    62122454..62135378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528607.2XP_011526909.1  protein LSM14 homolog B isoform X3

    Conserved Domains (2) summary
    pfam09532
    Location:323424
    FDF; FDF domain
    pfam12701
    Location:882
    LSM14; Scd6-like Sm domain
  2. XM_011528605.2XP_011526907.1  protein LSM14 homolog B isoform X1

    See identical proteins and their annotated locations for XP_011526907.1

    Conserved Domains (2) summary
    pfam09532
    Location:349450
    FDF; FDF domain
    pfam12701
    Location:882
    LSM14; Scd6-like Sm domain
  3. XM_024451839.1XP_024307607.1  protein LSM14 homolog B isoform X7

    Conserved Domains (2) summary
    cd01736
    Location:679
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:248349
    FDF; FDF domain
  4. XM_011528608.2XP_011526910.1  protein LSM14 homolog B isoform X4

    Conserved Domains (2) summary
    pfam09532
    Location:313414
    FDF; FDF domain
    pfam12701
    Location:882
    LSM14; Scd6-like Sm domain
  5. XM_017027688.2XP_016883177.1  protein LSM14 homolog B isoform X9

  6. XM_011528606.3XP_011526908.1  protein LSM14 homolog B isoform X2

    Conserved Domains (2) summary
    pfam09532
    Location:323424
    FDF; FDF domain
    pfam12701
    Location:882
    LSM14; Scd6-like Sm domain
  7. XM_011528611.3XP_011526913.1  protein LSM14 homolog B isoform X8

    See identical proteins and their annotated locations for XP_011526913.1

    Conserved Domains (2) summary
    pfam09532
    Location:222323
    FDF; FDF domain
    pfam12701
    Location:882
    LSM14; Scd6-like Sm domain
  8. XM_011528609.2XP_011526911.1  protein LSM14 homolog B isoform X6

    See identical proteins and their annotated locations for XP_011526911.1

    Conserved Domains (2) summary
    pfam09532
    Location:274375
    FDF; FDF domain
    pfam12701
    Location:882
    LSM14; Scd6-like Sm domain
  9. XM_005260302.3XP_005260359.1  protein LSM14 homolog B isoform X5

    See identical proteins and their annotated locations for XP_005260359.1

    Conserved Domains (2) summary
    pfam09532
    Location:287388
    FDF; FDF domain
    pfam12701
    Location:882
    LSM14; Scd6-like Sm domain
  10. XM_017027689.1XP_016883178.1  protein LSM14 homolog B isoform X12

  11. XM_024451840.1XP_024307608.1  protein LSM14 homolog B isoform X10

    Conserved Domains (1) summary
    pfam09532
    Location:204305
    FDF; FDF domain
  12. XM_011528613.2XP_011526915.1  protein LSM14 homolog B isoform X13

    See identical proteins and their annotated locations for XP_011526915.1

    Conserved Domains (1) summary
    pfam09532
    Location:168269
    FDF; FDF domain
  13. XM_024451842.1XP_024307610.1  protein LSM14 homolog B isoform X14

    Conserved Domains (1) summary
    pfam09532
    Location:93194
    FDF; FDF domain
  14. XM_024451844.1XP_024307612.1  protein LSM14 homolog B isoform X14

    Conserved Domains (1) summary
    pfam09532
    Location:93194
    FDF; FDF domain
  15. XM_024451843.1XP_024307611.1  protein LSM14 homolog B isoform X14

    Conserved Domains (1) summary
    pfam09532
    Location:93194
    FDF; FDF domain
  16. XM_011528612.2XP_011526914.1  protein LSM14 homolog B isoform X10

    See identical proteins and their annotated locations for XP_011526914.1

    Conserved Domains (1) summary
    pfam09532
    Location:204305
    FDF; FDF domain
  17. XM_011528614.2XP_011526916.1  protein LSM14 homolog B isoform X13

    See identical proteins and their annotated locations for XP_011526916.1

    Related
    ENSP00000355209.3, ENST00000361670.3
    Conserved Domains (1) summary
    pfam09532
    Location:168269
    FDF; FDF domain
  18. XM_024451841.1XP_024307609.1  protein LSM14 homolog B isoform X11

    Conserved Domains (1) summary
    pfam09532
    Location:203304
    FDF; FDF domain

RNA

  1. XR_936508.2 RNA Sequence

  2. XR_936509.2 RNA Sequence

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