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COMMD7 COMM domain containing 7 [ Homo sapiens (human) ]

Gene ID: 149951, updated on 1-Jun-2020

Summary

Official Symbol
COMMD7provided by HGNC
Official Full Name
COMM domain containing 7provided by HGNC
Primary source
HGNC:HGNC:16223
See related
Ensembl:ENSG00000149600 Ensembl:ENSG00000285382 MIM:616703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf92; dJ1085F17.3
Expression
Ubiquitous expression in thyroid (RPKM 17.9), placenta (RPKM 13.5) and 25 other tissues See more
Orthologs

Genomic context

See COMMD7 in Genome Data Viewer
Location:
20q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (32702691..32743472, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31290493..31331814, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7023 Neighboring gene BCL2 antagonist/killer 1 pseudogene 1 Neighboring gene DNA methyltransferase 3 beta Neighboring gene microtubule associated protein RP/EB family member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14987, MGC33315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NF-kappaB binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NF-kappaB binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COMM domain-containing protein 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099339.2NP_001092809.1  COMM domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001092809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK027893, BQ006261, DN993528
    Consensus CDS
    CCDS46587.1
    UniProtKB/Swiss-Prot
    Q86VX2
    Related
    ENSP00000395339.1, ENST00000446419.6
    Conserved Domains (1) summary
    cd04755
    Location:19197
    Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  2. NM_053041.3NP_444269.2  COMM domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_444269.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK027893, BG715846, BQ006261
    Consensus CDS
    CCDS42864.1
    UniProtKB/Swiss-Prot
    Q86VX2
    Related
    ENSP00000278980.6, ENST00000278980.10
    Conserved Domains (1) summary
    cd04755
    Location:19198
    Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    32702691..32743472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528604.3XP_011526906.1  COMM domain-containing protein 7 isoform X3

    Related
    ENSP00000494986.1, ENST00000642630.1
    Conserved Domains (1) summary
    cd04755
    Location:19175
    Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  2. XM_017027685.2XP_016883174.1  COMM domain-containing protein 7 isoform X4

  3. XM_017027686.2XP_016883175.1  COMM domain-containing protein 7 isoform X5

  4. XM_005260299.4XP_005260356.1  COMM domain-containing protein 7 isoform X1

    Conserved Domains (1) summary
    cd04755
    Location:19175
    Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  5. XM_005260300.4XP_005260357.1  COMM domain-containing protein 7 isoform X2

    Conserved Domains (1) summary
    cd04755
    Location:19174
    Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  6. XM_017027687.2XP_016883176.1  COMM domain-containing protein 7 isoform X6

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