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H2-Eb1 histocompatibility 2, class II antigen E beta [ Mus musculus (house mouse) ]

Gene ID: 14969, updated on 16-Oct-2021

Summary

Official Symbol
H2-Eb1provided by MGI
Official Full Name
histocompatibility 2, class II antigen E betaprovided by MGI
Primary source
MGI:MGI:95901
See related
Ensembl:ENSMUSG00000060586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eb; Ia4; H2Eb; Ia-4; H-2Eb
Expression
Biased expression in spleen adult (RPKM 375.3), large intestine adult (RPKM 229.1) and 12 other tissues See more
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Genomic context

See H2-Eb1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34524841..34535648)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34305867..34316674)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34442812..34453619)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, class II antigen A, beta 1 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene histocompatibility 2, class II antigen E beta2 Neighboring gene histocompatibility 2, class II antigen E alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163794, MGC163796

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC class II receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables polysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class II protein complex TAS
Traceable Author Statement
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
H-2 class II histocompatibility antigen, I-E beta chain
Names
I-E beta MHC class II
MHC H2-IE-beta cell surface glycoprotein
MHC class II IE-b
cell surface glycoprotein
histocompatibility 2, class II antigen E beta, promoter 1
major histocompatibility complex H-2E beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010382.2NP_034512.2  H-2 class II histocompatibility antigen, I-E beta chain precursor

    See identical proteins and their annotated locations for NP_034512.2

    Status: VALIDATED

    Source sequence(s)
    AK160485, BY202562, CAAA01111730
    Consensus CDS
    CCDS37584.1
    UniProtKB/TrEMBL
    O78196
    Related
    ENSMUSP00000158533.2, ENSMUST00000235530.2
    Conserved Domains (2) summary
    pfam00969
    Location:40114
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:124217
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34524841..34535648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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