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ADIG adipogenin [ Homo sapiens (human) ]

Gene ID: 149685, updated on 1-Jun-2020

Summary

Official Symbol
ADIGprovided by HGNC
Official Full Name
adipogeninprovided by HGNC
Primary source
HGNC:HGNC:28606
See related
Ensembl:ENSG00000182035 MIM:611396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMAF1
Summary
ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008]
Expression
Restricted expression toward testis (RPKM 13.2) See more
Orthologs

Genomic context

See ADIG in Genome Data Viewer
Location:
20q11.23
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (38581197..38588463)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37209838..37217104)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein non-catalytic subunit beta Neighboring gene microRNA 548o-2 Neighboring gene ribosomal protein S3 pseudogene 2 Neighboring gene Rho GTPase activating protein 40 Neighboring gene GINS complex subunit 2 (Psf2 homolog) pseudogene Neighboring gene GATA motif-containing MPRA enhancer 112/113

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • KIAA1219, MGC39724, MGC149650

Gene Ontology Provided by GOA

Process Evidence Code Pubs
brown fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
white fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
white fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid droplet IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
adipogenin
Names
adipogenesis associated
small adipocyte factor 1 (SMAF1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018082.3NP_001018092.1  adipogenin

    See identical proteins and their annotated locations for NP_001018092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the conserved protein.
    Source sequence(s)
    AA974242, AL035419, BC029594, BX105371
    Consensus CDS
    CCDS54461.1
    UniProtKB/Swiss-Prot
    Q0VDE8
    UniProtKB/TrEMBL
    A0A158RFT8
    Related
    ENSP00000434385.1, ENST00000470147.5
    Conserved Domains (1) summary
    pfam15202
    Location:178
    Adipogenin; Adipogenin

RNA

  1. NR_130907.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon results in an open reading frame without a stop codon. This transcript is a candidate for non-stop decay.
    Source sequence(s)
    AA974242, AI990489, AL035419, BC029594
    Related
    ENST00000416116.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    38581197..38588463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_174906.3: Suppressed sequence

    Description
    NM_174906.3: This RefSeq was permanently suppressed because it contains the wrong CDS.
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