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RNF187 ring finger protein 187 [ Homo sapiens (human) ]

Gene ID: 149603, updated on 24-Nov-2020

Summary

Official Symbol
RNF187provided by HGNC
Official Full Name
ring finger protein 187provided by HGNC
Primary source
HGNC:HGNC:27146
See related
Ensembl:ENSG00000168159 MIM:613754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RACO1; RACO-1
Expression
Ubiquitous expression in thyroid (RPKM 54.8), brain (RPKM 49.5) and 25 other tissues See more
Orthologs

Genomic context

See RNF187 in Genome Data Viewer
Location:
1q42.13
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228487382..228496188)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228674277..228697598)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 4666a Neighboring gene H2B.U histone 2, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4602 Neighboring gene Sharpr-MPRA regulatory region 4759 Neighboring gene uncharacterized LOC105373124 Neighboring gene butyrophilin like 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF187
Names
RING domain AP1 coactivator 1
RING-type E3 ubiquitin transferase RNF187
protein RNF187
ring domain AP-1 co-activator 1
NP_001010858.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010858.3NP_001010858.2  E3 ubiquitin-protein ligase RNF187

    See identical proteins and their annotated locations for NP_001010858.2

    Status: VALIDATED

    Source sequence(s)
    AL139288, BC012758, BI551408
    Consensus CDS
    CCDS76271.1
    UniProtKB/Swiss-Prot
    Q5TA31
    Related
    ENSP00000306396.8, ENST00000305943.8
    Conserved Domains (1) summary
    pfam00097
    Location:1252
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    228487382..228496188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654708.1 Reference GRCh38.p13 PATCHES

    Range
    78581..87387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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