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H1f0 H1.0 linker histone [ Mus musculus (house mouse) ]

Gene ID: 14958, updated on 8-Jan-2023

Summary

Official Symbol
H1f0provided by MGI
Official Full Name
H1.0 linker histoneprovided by MGI
Primary source
MGI:MGI:95893
See related
Ensembl:ENSMUSG00000096210 AllianceGenome:MGI:95893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H1-0; H1fv; H1(0); D130017D06Rik
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Orthologs
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Genomic context

See H1f0 in Genome Data Viewer
Location:
15 E1; 15 37.7 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78912412..78914704)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79028212..79030504)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene TRIO and F-actin binding protein Neighboring gene predicted gene 10865 Neighboring gene microRNA 6956 Neighboring gene predicted gene, 17753 Neighboring gene glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) Neighboring gene galanin receptor 3 Neighboring gene predicted gene 3924

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC19309, MGC98218, MGC117919

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding EXP
Inferred from Experiment
more info
PubMed 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables minor groove of adenine-thymine-rich DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H1.0
Names
H1 histone family, member 0
H1-0 histone
histone H1'
histone H1(0)
myD196

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008197.3NP_032223.2  histone H1.0

    See identical proteins and their annotated locations for NP_032223.2

    Status: REVIEWED

    Source sequence(s)
    AI849476, AK051213, BB661016
    Consensus CDS
    CCDS56990.1
    UniProtKB/Swiss-Prot
    P10922, Q3UKC0
    UniProtKB/TrEMBL
    A0A8C6HSK0
    Related
    ENSMUSP00000137309.2, ENSMUST00000180086.3
    Conserved Domains (1) summary
    pfam00538
    Location:2596
    Linker_histone; linker histone H1 and H5 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78912412..78914704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)