U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H1f3 H1.3 linker histone, cluster member [ Mus musculus (house mouse) ]

Gene ID: 14957, updated on 26-Sep-2022

Summary

Official Symbol
H1f3provided by MGI
Official Full Name
H1.3 linker histone, cluster memberprovided by MGI
Primary source
MGI:MGI:107502
See related
Ensembl:ENSMUSG00000052565 AllianceGenome:MGI:107502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H1D; H1-3; H1.3; H1s-4; Hist1h1d
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H1f3 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23739206..23739981)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23555032..23555807)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H3 clustered histone 7 Neighboring gene H4 clustered histone 6 Neighboring gene H3 clustered histone 6 Neighboring gene H2A clustered histone 8

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
histone H1.3
Names
H1 VAR.4
H1 histone family, member 3
histone 1, H1d
histone 1, family 3
histone cluster 1, H1d

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145713.4NP_663759.3  histone H1.3

    See identical proteins and their annotated locations for NP_663759.3

    Status: REVIEWED

    Source sequence(s)
    AL592149
    Consensus CDS
    CCDS26346.1
    UniProtKB/Swiss-Prot
    P43277, Q8C6M4
    UniProtKB/TrEMBL
    Q149Z9
    Related
    ENSMUSP00000044395.7, ENSMUST00000045301.9
    Conserved Domains (1) summary
    cd00073
    Location:35115
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23739206..23739981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)