SRARP steroid receptor associated and regulated protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRARPprovided by HGNC
Official Full Name: steroid receptor associated and regulated proteinprovided by HGNC
Primary source: HGNC:HGNC:28339
See related: Ensembl:ENSG00000183888 MIM:619448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ERRF; C1orf64
Expression: Biased expression in endometrium (RPKM 2.9), salivary gland (RPKM 2.4) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (16004236..16008807)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (16330731..16335302)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRARP and HSPB7 are tumor suppressors that are commonly inactivated in malignancies.
Title: SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies.
Further mechanism study proved ERRF to be an interacting partner of ERalpha. In total, these data revealed that ERRF is essential for the activity of E2-ERalpha pathway.
Title: ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells.
These results suggest that ERRF plays a role in estrogen-ER-mediated growth of breast cancer cells.
Title: Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the SRARP gene: The SRARP gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 157 organisms have orthologs with human gene SRARP
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables estrogen receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of intracellular estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: steroid receptor-associated and regulated protein

Names: ER-related factor; steroid receptor-regulated protein; uncharacterized protein C1orf64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.