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SRARP steroid receptor associated and regulated protein [ Homo sapiens (human) ]

Gene ID: 149563, updated on 9-Jun-2025
Official Symbol
SRARPprovided by HGNC
Official Full Name
steroid receptor associated and regulated proteinprovided by HGNC
Primary source
HGNC:HGNC:28339
See related
Ensembl:ENSG00000183888 MIM:619448; AllianceGenome:HGNC:28339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERRF; C1orf64
Summary
Enables nuclear estrogen receptor binding activity. Involved in positive regulation of intracellular estrogen receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in endometrium (RPKM 2.9), salivary gland (RPKM 2.4) and 4 other tissues See more
Orthologs
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See SRARP in Genome Data Viewer
Location:
1p36.13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (16004236..16008807)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (15445552..15450118)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16330731..16335302)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 17 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16276391-16277178 Neighboring gene uncharacterized LOC124903855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 254 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:16278891-16280090 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:16287659-16288532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 318 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 319 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16302461-16302960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16320391-16321231 Neighboring gene TBC1 domain family member 3 pseudogene 6 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:16330551-16331416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16343340-16344086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16344087-16344831 Neighboring gene heat shock protein family B (small) member 7 Neighboring gene CLCNKA recombination region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16352537-16353445 Neighboring gene chloride voltage-gated channel Ka Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16356923-16357422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16358660-16359467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16359468-16360274

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC24047

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear estrogen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
steroid receptor-associated and regulated protein
Names
ER-related factor
estrogen receptor-related factor
steroid receptor-regulated protein
uncharacterized protein C1orf64

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178840.4NP_849162.1  steroid receptor-associated and regulated protein

    See identical proteins and their annotated locations for NP_849162.1

    Status: VALIDATED

    Source sequence(s)
    AI732325, AL355994, AW299952, DA387602
    Consensus CDS
    CCDS166.1
    UniProtKB/Swiss-Prot
    B3KXI9, Q8NEQ6
    Related
    ENSP00000332162.2, ENST00000329454.2
    Conserved Domains (1) summary
    pfam15547
    Location:34169
    DUF4654; Domain of unknown function (DUF4654)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    16004236..16008807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    15445552..15450118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)