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PRRSVgp1 ORF 1ab polyprotein [ Porcine reproductive and respiratory syndrome virus ]

Gene ID: 1494884, updated on 11-Jul-2020

Summary

Gene symbol
PRRSVgp1
Gene description
ORF 1ab polyprotein
Locus tag
PRRSVgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Porcine reproductive and respiratory syndrome virus
Lineage
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Nidovirales; Arteriviridae; unclassified Arteriviridae
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Genomic context

Sequence:
NC_001961.1 (190..12071)

NC_001961.1Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein Neighboring gene 1aTF polyprotein Neighboring gene E protein Neighboring gene GP2 glycosylated envelope protein Neighboring gene GP3 envelope protein Neighboring gene GP4

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Miscellaneous features

  • Loc: 7689-7760 function = frameshift [minus 1] at ORF1a/1b junction , standard_name = ribosomal frameshift region

General protein information

Preferred Names
ORF 1ab polyprotein
Names
nsp1 (pcp1a and pcp1b)
nsp2
hydrophobic protein
3C-like serine proteinase
hydrophobic protein 2
nsp6
nsp7
RNA-dependent RNA polymerase
nsp10 (MB, NTPase, HEL)
nsp11
nsp12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001961.1 Reference assembly

    Range
    190..12071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_066135.1 ORF 1ab polyprotein [Porcine reproductive and respiratory syndrome virus]

    Status: PROVISIONAL

    Conserved Domains (10) summary
    pfam05412
    Location:428535
    Peptidase_C33; Equine arterivirus Nsp2-type cysteine proteinase
    pfam05410
    Location:57161
    Peptidase_C31; Porcine arterivirus-type cysteine proteinase alpha
    pfam05411
    Location:256382
    Peptidase_C32; Equine arteritis virus putative proteinase
    pfam05579
    Location:17172014
    Peptidase_S32; Equine arteritis virus serine endopeptidase S32
    pfam14756
    Location:536682
    Pdase_C33_assoc; Peptidase_C33-associated domain
    pfam14757
    Location:8041075
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
    pfam01443
    Location:32923515
    Viral_helicase1; Viral (Superfamily 1) RNA helicase
    pfam16749
    Location:22012328
    Arteri_nsp7a; Arterivirus nonstructural protein 7 alpha
    cl02808
    Location:28363075
    RT_like; RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
    cl22977
    Location:34713514
    UvrD_C_2; UvrD-like helicase C-terminal domain
  2. NP_740595.1 nsp1 (pcp1a and pcp1b)

    Conserved Domains (2) summary
    pfam05410
    Location:57161
    Peptidase_C31; Porcine arterivirus-type cysteine proteinase alpha
    pfam05411
    Location:256382
    Peptidase_C32; Equine arteritis virus putative proteinase
  3. NP_740596.1 nsp2

    Conserved Domains (3) summary
    pfam05412
    Location:46153
    Peptidase_C33; Equine arterivirus Nsp2-type cysteine proteinase
    pfam14756
    Location:154300
    Pdase_C33_assoc; Peptidase_C33-associated domain
    pfam14757
    Location:422693
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  4. NP_740597.1 hydrophobic protein

    Conserved Domains (1) summary
    pfam05579
    Location:139231
    Peptidase_S32; Equine arteritis virus serine endopeptidase S32
  5. NP_740598.1 3C-like serine proteinase

    Conserved Domains (1) summary
    pfam05579
    Location:1204
    Peptidase_S32; Equine arteritis virus serine endopeptidase S32
  6. NP_740599.1 hydrophobic protein 2

  7. NP_740600.1 nsp6

  8. NP_740601.1 nsp7

    Conserved Domains (1) summary
    pfam16749
    Location:2129
    Arteri_nsp7a; Arterivirus nonstructural protein 7 alpha
  9. NP_740602.1 RNA-dependent RNA polymerase

    Conserved Domains (1) summary
    cl02808
    Location:378617
    RT_like; RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
  10. NP_740603.1 nsp10 (MB, NTPase, HEL)

    Conserved Domains (3) summary
    pfam01443
    Location:149372
    Viral_helicase1; Viral (Superfamily 1) RNA helicase
    cl18310
    Location:354407
    NHL; NHL repeat unit of beta-propeller proteins
    cl22977
    Location:328371
    UvrD_C_2; UvrD-like helicase C-terminal domain
  11. NP_740604.1 nsp11

  12. NP_740605.1 nsp12

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