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BNIPL BCL2 interacting protein like [ Homo sapiens (human) ]

Gene ID: 149428, updated on 11-Jun-2021

Summary

Official Symbol
BNIPLprovided by HGNC
Official Full Name
BCL2 interacting protein likeprovided by HGNC
Primary source
HGNC:HGNC:16976
See related
Ensembl:ENSG00000163141 MIM:611275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BNIPS; PP753; BNIP-S; BNIPL1; BNIPL2; BNIPL-1; BNIPL-2; BNIP-Sbeta; BNIP-Salpha
Summary
The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Expression
Biased expression in skin (RPKM 64.5), esophagus (RPKM 30.1) and 1 other tissue See more
Orthologs
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Genomic context

See BNIPL in Genome Data Viewer
Location:
1q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151036321..151047720)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151009062..151020196)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene prune exopolyphosphatase 1 Neighboring gene RNA, U6 small nuclear 884, pseudogene Neighboring gene chromosome 1 open reading frame 56 Neighboring gene CDC42 small effector 1 Neighboring gene MLLT11 transcription factor 7 cofactor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables exopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in polyphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of growth rate IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
Names
BCL2/adenovirus E1B 19kD interacting protein like
BNIP-2 similar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029720.1 RefSeqGene

    Range
    5034..16168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159642.2NP_001153114.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform b

    See identical proteins and their annotated locations for NP_001153114.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at an exon in the 5' region compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (b, also known as BNIP-Salpha) with a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AF193056, AK092595, AL590133, CD687603, CU451236
    Consensus CDS
    CCDS53362.1
    UniProtKB/Swiss-Prot
    Q7Z465
    Related
    ENSP00000295294.7, ENST00000295294.11
    Conserved Domains (2) summary
    pfam12496
    Location:1129
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:131256
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  2. NM_138278.4NP_612122.2  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform a

    See identical proteins and their annotated locations for NP_612122.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK092595, AL590133, BC027868, CU451236
    Consensus CDS
    CCDS978.2
    UniProtKB/Swiss-Prot
    Q7Z465
    Related
    ENSP00000357927.3, ENST00000368931.8
    Conserved Domains (2) summary
    pfam12496
    Location:83211
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:213350
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151036321..151047720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453491.1XP_024309259.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform X2

    Conserved Domains (2) summary
    pfam12496
    Location:1129
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:131256
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  2. XM_024453496.1XP_024309264.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform X2

    Conserved Domains (2) summary
    pfam12496
    Location:1129
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:131256
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  3. XM_011509236.1XP_011507538.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform X1

    Conserved Domains (2) summary
    pfam12496
    Location:83211
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:213324
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  4. XM_017000420.1XP_016855909.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform X3

    Conserved Domains (2) summary
    pfam12496
    Location:145
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:47172
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RNA

  1. XR_921747.1 RNA Sequence

  2. XR_921748.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138279.2: Suppressed sequence

    Description
    NM_138279.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein and the transcript is a nonsense-mediated mRNA decay (NMD) candidate.
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