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PDIK1L PDLIM1 interacting kinase 1 like [ Homo sapiens (human) ]

Gene ID: 149420, updated on 1-Jun-2020

Summary

Official Symbol
PDIK1Lprovided by HGNC
Official Full Name
PDLIM1 interacting kinase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:18981
See related
Ensembl:ENSG00000175087 MIM:610785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLIK1L; STK35L2
Expression
Ubiquitous expression in thyroid (RPKM 7.2), bone marrow (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See PDIK1L in Genome Data Viewer
Location:
1p36.11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (26109131..26125555)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26437656..26452039)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 63 Neighboring gene VISTA enhancer hs2271 Neighboring gene uncharacterized LOC105376886 Neighboring gene family with sequence similarity 110 member D Neighboring gene chromosome 1 open reading frame 230

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PDIK1L
Names
casein kinase
NP_001230461.1
NP_001230462.1
NP_690048.1
XP_005245800.1
XP_006710444.1
XP_011539094.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243532.1NP_001230461.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_001230461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL834290, BU742621, CV024336, DA221039, DB233669
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    Q8N165
    Related
    ENSP00000480635.1, ENST00000619836.4
    Conserved Domains (1) summary
    cd13977
    Location:7331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like
  2. NM_001243533.2NP_001230462.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_001230462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AF411102, AL391650, BU742621, DB227864
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    Q8N165
    Related
    ENSP00000363389.4, ENST00000374271.8
    Conserved Domains (1) summary
    cd13977
    Location:7331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like
  3. NM_152835.5NP_690048.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_690048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK312872, AL391650, AL834290, BU742621
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    Q8N165
    Related
    ENSP00000363387.1, ENST00000374269.2
    Conserved Domains (1) summary
    cd13977
    Location:7331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    26109131..26125555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710381.4XP_006710444.1  serine/threonine-protein kinase PDIK1L isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:18253
    PKc_like; Protein Kinases, catalytic domain
  2. XM_005245743.4XP_005245800.1  serine/threonine-protein kinase PDIK1L isoform X1

    See identical proteins and their annotated locations for XP_005245800.1

    UniProtKB/Swiss-Prot
    Q8N165
    Conserved Domains (1) summary
    cd13977
    Location:7331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like
  3. XM_011540792.2XP_011539094.1  serine/threonine-protein kinase PDIK1L isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:30241
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:4247
    PKc_like; Protein Kinases, catalytic domain
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