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PDIK1L PDLIM1 interacting kinase 1 like [ Homo sapiens (human) ]

Gene ID: 149420, updated on 5-Aug-2022

Summary

Official Symbol
PDIK1Lprovided by HGNC
Official Full Name
PDLIM1 interacting kinase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:18981
See related
Ensembl:ENSG00000175087 MIM:610785; AllianceGenome:HGNC:18981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLIK1L; STK35L2
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 7.2), bone marrow (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

See PDIK1L in Genome Data Viewer
Location:
1p36.11
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26111162..26125555)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25948595..25962987)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26437653..26452046)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4919 Neighboring gene tripartite motif containing 63 Neighboring gene VISTA enhancer hs2271 Neighboring gene Sharpr-MPRA regulatory region 12487 Neighboring gene Sharpr-MPRA regulatory region 4586 Neighboring gene family with sequence similarity 110 member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase PDIK1L
Names
casein kinase
NP_001230461.1
NP_001230462.1
NP_690048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243532.2NP_001230461.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_001230461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL391650, AL834290, BU742621, CV024336, DA221039, DB233669
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    Q8N165, Q8NDB3
    Related
    ENSP00000480635.1, ENST00000619836.4
    Conserved Domains (1) summary
    cd13977
    Location:7331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like
  2. NM_001243533.2NP_001230462.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_001230462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AF411102, AL391650, BU742621, DB227864
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    Q8N165, Q8NDB3
    Related
    ENSP00000363389.4, ENST00000374271.8
    Conserved Domains (1) summary
    cd13977
    Location:7331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like
  3. NM_152835.5NP_690048.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_690048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK312872, AL391650, AL834290, BU742621
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    Q8N165, Q8NDB3
    Related
    ENSP00000363387.1, ENST00000374269.2
    Conserved Domains (1) summary
    cd13977
    Location:7331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26111162..26125555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    25948595..25962987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)