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Gzmd granzyme D [ Mus musculus (house mouse) ]

Gene ID: 14941, updated on 5-Jan-2023

Summary

Official Symbol
Gzmdprovided by MGI
Official Full Name
granzyme Dprovided by MGI
Primary source
MGI:MGI:109255
See related
Ensembl:ENSMUSG00000059256 AllianceGenome:MGI:109255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCP5; Ctla5; Ctla-5
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Predicted to act upstream of or within cytolysis. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in extraembryonic component and placenta. Orthologous to human GZMB (granzyme B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 32.6) See more
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Genomic context

See Gzmd in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56367013..56370060, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56129556..56132603, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene cathepsin G Neighboring gene granzyme E Neighboring gene small nucleolar RNA SNORD55/SNORD39 Neighboring gene granzyme G

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cytolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in granzyme-mediated programmed cell death signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytolytic granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010372.2NP_034502.2  granzyme D precursor

    See identical proteins and their annotated locations for NP_034502.2

    Status: VALIDATED

    Source sequence(s)
    AK131671
    Consensus CDS
    CCDS49502.1
    UniProtKB/Swiss-Prot
    P11033, Q3V2P1
    Related
    ENSMUSP00000080742.7, ENSMUST00000082093.7
    Conserved Domains (2) summary
    smart00020
    Location:20245
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:21248
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56367013..56370060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518569.4XP_006518632.2  granzyme D isoform X1

    See identical proteins and their annotated locations for XP_006518632.2

    Conserved Domains (1) summary
    smart00020
    Location:20241
    Tryp_SPc; Trypsin-like serine protease