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Gzmc granzyme C [ Mus musculus (house mouse) ]

Gene ID: 14940, updated on 8-Feb-2024

Summary

Official Symbol
Gzmcprovided by MGI
Official Full Name
granzyme Cprovided by MGI
Primary source
MGI:MGI:109256
See related
Ensembl:ENSMUSG00000079186 AllianceGenome:MGI:109256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B10; CCP2; Ctla5; Ctla-5
Summary
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells. This gene is present in a gene cluster with other members of the granzyme subfamily on chromosome 14. [provided by RefSeq, Sep 2015]
Expression
Biased expression in placenta adult (RPKM 7.5) and subcutaneous fat pad adult (RPKM 0.6) See more
Orthologs
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Genomic context

See Gzmc in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56468854..56479102, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56231397..56241647, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57615 Neighboring gene granzyme F Neighboring gene STARR-seq mESC enhancer starr_36794 Neighboring gene predicted gene, 24118 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene granzyme B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytolytic granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
granzyme C
Names
cytotoxic cell protease 2
NP_001409139.1
NP_034501.2
XP_011243265.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001422210.1NP_001409139.1  granzyme C preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC091783
    UniProtKB/Swiss-Prot
    P08882, Q61389
    UniProtKB/TrEMBL
    Q0VB76
  2. NM_010371.4NP_034501.2  granzyme C preproprotein

    See identical proteins and their annotated locations for NP_034501.2

    Status: REVIEWED

    Source sequence(s)
    AC091783
    Consensus CDS
    CCDS27146.1
    UniProtKB/Swiss-Prot
    P08882, Q61389
    UniProtKB/TrEMBL
    Q0VB76
    Related
    ENSMUSP00000015585.3, ENSMUST00000015585.4
    Conserved Domains (1) summary
    cd00190
    Location:21244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56468854..56479102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244963.4XP_011243265.1  granzyme C isoform X1

    See identical proteins and their annotated locations for XP_011243265.1

    UniProtKB/Swiss-Prot
    P08882, Q61389
    UniProtKB/TrEMBL
    Q0VB76
    Conserved Domains (1) summary
    cd00190
    Location:21244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...