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Gzmb granzyme B [ Mus musculus (house mouse) ]

Gene ID: 14939, updated on 8-Feb-2024

Summary

Official Symbol
Gzmbprovided by MGI
Official Full Name
granzyme Bprovided by MGI
Primary source
MGI:MGI:109267
See related
Ensembl:ENSMUSG00000015437 AllianceGenome:MGI:109267
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GZB; CCP1; Ctla1; Ctla-1; CCP-1/C11
Summary
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]
Expression
Biased expression in large intestine adult (RPKM 11.7), small intestine adult (RPKM 4.9) and 8 other tissues See more
Orthologs
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Genomic context

See Gzmb in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56496293..56499791, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56258836..56262334, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene granzyme C Neighboring gene predicted gene, 24118 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene high mobility group protein B1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56915695-56915848 Neighboring gene ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytolytic granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytolytic granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
granzyme B(G,H)
Names
cytotoxic cell protease 1
fragmentin-2
NP_038570.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013542.3NP_038570.1  granzyme B(G,H) preproprotein

    See identical proteins and their annotated locations for NP_038570.1

    Status: REVIEWED

    Source sequence(s)
    AC091783, AK157856, BU758224, BY227723
    Consensus CDS
    CCDS27147.1
    UniProtKB/Swiss-Prot
    P04187
    UniProtKB/TrEMBL
    Q3TIP3, Q3TZH4, Q4FJY0
    Related
    ENSMUSP00000015581.5, ENSMUST00000015581.6
    Conserved Domains (2) summary
    smart00020
    Location:20240
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:21243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56496293..56499791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)