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SHISA4 shisa family member 4 [ Homo sapiens (human) ]

Gene ID: 149345, updated on 22-Sep-2022

Summary

Official Symbol
SHISA4provided by HGNC
Official Full Name
shisa family member 4provided by HGNC
Primary source
HGNC:HGNC:27139
See related
Ensembl:ENSG00000198892 MIM:617326; AllianceGenome:HGNC:27139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM58; C1orf40
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 26.3), heart (RPKM 17.4) and 19 other tissues See more
Orthologs
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Genomic context

See SHISA4 in Genome Data Viewer
Location:
1q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (201888677..201892587)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (201146432..201150342)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201857805..201861715)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene importin 9 Neighboring gene Sharpr-MPRA regulatory region 11581 Neighboring gene microRNA 6739 Neighboring gene Sharpr-MPRA regulatory region 2190 Neighboring gene leiomodin 1 Neighboring gene translocase of inner mitochondrial membrane 17A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18233, MGC102893, MGC129812, MGC129813

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein shisa-4
Names
shisa homolog 4
transmembrane protein 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198149.3NP_937792.2  protein shisa-4 precursor

    See identical proteins and their annotated locations for NP_937792.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AK294106, BC111855
    Consensus CDS
    CCDS1416.1
    UniProtKB/Swiss-Prot
    Q6UWY7, Q96DD7
    Related
    ENSP00000355064.7, ENST00000362011.7
    Conserved Domains (1) summary
    pfam13908
    Location:28177
    Shisa; Wnt and FGF inhibitory regulator

RNA

  1. NR_030775.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1 and as a result lacks the start codon used in variant 1. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because there is uncertainty about the protein-coding capacity of the transcript.
    Source sequence(s)
    AK294106, AL513217, BM923401, DA130234

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    201888677..201892587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    201146432..201150342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)