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ORF1 nonstructural polyprotein [ Norovirus GI ]

Gene ID: 1491970, updated on 6-Jun-2024
Gene symbol
ORF1
Gene description
nonstructural polyprotein
Locus tag
NoVGI_gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Norovirus GI
Lineage
Viruses; Riboviria; Caliciviridae; Norovirus
Old locus tag
NVgp1
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Sequence:
NC_001959.2 (5..5374)

NC_001959.2Genomic Context describing neighboring genes Neighboring gene VP1 Neighboring gene VP2

Genomic Sequence:
NC_001959.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences. Shaik MM, et al. Proteins, 2017 Aug. PMID 28383118
  2. The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order. May J, et al. J Virol, 2014 Sep. PMID 24991013, Free PMC Article
  3. Structural basis of substrate specificity and protease inhibition in Norwalk virus. Muhaxhiri Z, et al. J Virol, 2013 Apr. PMID 23365454, Free PMC Article
  4. Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay. Chang KO, et al. Virology, 2012 Feb 20. PMID 22200497, Free PMC Article
  5. Completion of the Norwalk virus genome sequence. Hardy ME, et al. Virus Genes, 1996. PMID 8883366

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A computational study of the norovirus RNA-dependent RNA polymerase revealed its metal-binding preferences.
    Title: Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences.
  2. Protease processing at ORF1 cleavage sites is primarily regulated by the P4-P2' sequences.
    Title: The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order.
  3. In the X-ray structure of a Norwalk virus protease construct, authors observed that the C-terminal tail, representing the native substrate positions P5 to P1, is inserted into the active site cleft of the neighboring protease molecule.
    Title: Structural basis of substrate specificity and protease inhibition in Norwalk virus.
  4. The protease of Norwalk virus and MD145 exhibited enzymatic activity with similar cleavage efficiency on each substrate.
    Title: Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay.
Submit: New GeneRIF Correction
Preferred Names
nonstructural polyprotein
Names
p48
NTPase
p22
VPg
Pro
RdRp
NP_056820.1
  • ORF1; sequence homologies to 2C helicase, 3C protease, and 3D RNA-dependent RNA polymerase of picornavirus

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001959.2 Reference assembly

    Range
    5..5374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_056820.1 nonstructural polyprotein [Norovirus GI]

    See identical proteins and their annotated locations for NP_056820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q83883
    UniProtKB/TrEMBL
    I2AMH8, R4ULS6, R4ULU5, R4UPK9, R4UPM5, R4UXU0, R4V2Y9, R4V318, S5Y3T4
    Conserved Domains (4) summary
    pfam05416
    Location:706 → 1269
    Peptidase_C37; Southampton virus-type processing peptidase
    pfam00680
    Location:1300 → 1766
    RdRP_1; RNA dependent RNA polymerase
    pfam00910
    Location:556 → 657
    RNA_helicase; RNA helicase
    pfam08405
    Location:183 → 540
    Calici_PP_N; Viral polyprotein N-terminal

  2. NP_786945.1 p48

    Conserved Domains (1) summary
    pfam08405
    Location:183 → 398
    Calici_PP_N; Viral polyprotein N-terminal

  3. NP_786946.1 NTPase

    Conserved Domains (3) summary
    pfam05416
    Location:308 → 363
    Peptidase_C37; Southampton virus-type processing peptidase
    pfam00910
    Location:158 → 259
    RNA_helicase; RNA helicase
    pfam08405
    Location:1 → 142
    Calici_PP_N; Viral polyprotein N-terminal

  4. NP_786947.1 p22

    Conserved Domains (1) summary
    pfam05416
    Location:1 → 201
    Peptidase_C37; Southampton virus-type processing peptidase

  5. NP_786948.1 VPg

    Conserved Domains (1) summary
    pfam05416
    Location:17 → 138
    Peptidase_C37; Southampton virus-type processing peptidase

  6. NP_786949.1 Pro

    UniProtKB/TrEMBL
    G1FEL5
    Conserved Domains (1) summary
    pfam05416
    Location:1 → 169
    Peptidase_C37; Southampton virus-type processing peptidase

  7. NP_786950.1 RdRp

    Conserved Domains (1) summary
    pfam00680
    Location:19 → 485
    RdRP_1; RNA dependent RNA polymerase
Protein Accession Links
GenPept Link UniProtKB Link
AAB50465.1

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