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gag Pr55 [ Human T-cell leukemia virus type I ]

Gene ID: 1491934, updated on 16-Jun-2026
Gene symbol
gag
Gene description
Pr55
Locus tag
HTLV1gp3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human T-cell leukemia virus type I
Lineage
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus
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Sequence:
NC_001436.1 (450..1739)

NC_001436.1Genomic Context describing neighboring genes Neighboring gene Pr gag-pro Neighboring gene Pr gag-pro-pol Neighboring gene Neighboring gene Neighboring gene p27 Neighboring gene protein-coding Neighboring gene p40

Genomic Sequence:
NC_001436.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Molecular Determinants of Human T-cell Leukemia Virus Type 1 Gag Targeting to the Plasma Membrane for Assembly. Herrmann D, et al. J Mol Biol, 2022 Jun 30. PMID 35490898, Free PMC Article
  2. Localization of human T-cell lymphotropic virus-1 gag proviral sequences in dermato-immunological disorders with eosinophilia. Nagy K, et al. Acta Microbiol Immunol Hung, 2005. PMID 16400878
  3. Structural and dynamics studies of the D54A mutant of human T cell leukemia virus-1 capsid protein. Bouamr F, et al. J Biol Chem, 2005 Feb 25. PMID 15569685
  4. Interaction of TSG101 with the PTAP Motif in Distinct Locations of Gag Determines the Incorporation of HTLV-1 Env into the Retroviral Virion. Maeda Y, et al. Int J Mol Sci, 2023 Nov 20. PMID 38003710, Free PMC Article
  5. Phosphorylation of the HTLV-1 matrix L-domain-containing protein by virus-associated ERK-2 kinase. Hémonnot B, et al. Virology, 2006 Jun 5. PMID 16635502

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of TSG101 with the PTAP Motif in Distinct Locations of Gag Determines the Incorporation of HTLV-1 Env into the Retroviral Virion.
    Title: Interaction of TSG101 with the PTAP Motif in Distinct Locations of Gag Determines the Incorporation of HTLV-1 Env into the Retroviral Virion.
  2. Molecular Determinants of Human T-cell Leukemia Virus Type 1 Gag Targeting to the Plasma Membrane for Assembly.
    Title: Molecular Determinants of Human T-cell Leukemia Virus Type 1 Gag Targeting to the Plasma Membrane for Assembly.
  3. Altogether, these data suggest that Gag targeting and membrane binding mediated by HTLV-1 matrix domain does not require phosphatidylinositol-(4,5)-bisphosphate and that distinct mechanisms regulate HIV-1 and HTLV-1 Gag membrane binding.
    Title: Gag localization and virus-like particle release mediated by the matrix domain of human T-lymphotropic virus type 1 Gag are less dependent on phosphatidylinositol-(4,5)-bisphosphate than those mediated by the matrix domain of HIV-1 Gag.
  4. HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively.
    Title: Localization of human T-cell lymphotropic virus-1 gag proviral sequences in dermato-immunological disorders with eosinophilia.
  5. findings have shown that HTLV-1 Gag associates with CD82-enriched plasma membrane microdomains in Jurkat T cells
    Title: HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane.
  6. data show that the HTLV-1 matrix protein may be phosphorylated by cellular ERK-2 kinase and indicate that phosphorylation of L-domain-containing proteins may be a common post-translational modification required for appropriate retroviruses budding
    Title: Phosphorylation of the HTLV-1 matrix L-domain-containing protein by virus-associated ERK-2 kinase.
  7. beta-hairpin contributes to overall structure of mature capsid protein; differences in the backbone dynamics of the beta-hairpin contribute to mature capsid structure, possibly introducing flexibility into interface formation during proteolytic maturation
    Title: Structural and dynamics studies of the D54A mutant of human T cell leukemia virus-1 capsid protein.
  8. Nedd4.1 and Tsg101 act successively in the assembly process of HTLV-1 to ensure proper Gag trafficking through the endocytic pathway up to late endosomes where the late steps of retroviral release occur
    Title: Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding.
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Homology

Preferred Names
Pr55
Names
p19 MA
p24 CA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001436.1 Reference assembly

    Range
    450..1739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057862.1 Pr55 [Human T-cell leukemia virus type I]

    See identical proteins and their annotated locations for NP_057862.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O56229, P14076
    UniProtKB/TrEMBL
    A0A6H1QUQ9
    Conserved Domains (3) summary
    smart00343
    Location:357 → 372
    ZnF_C2HC; zinc finger
    pfam00607
    Location:147 → 344
    Gag_p24; gag gene protein p24 (core nucleocapsid protein)
    pfam02228
    Location:1 → 92
    Gag_p19; Major core protein p19

  2. NP_955617.1 p19 MA

    Conserved Domains (1) summary
    pfam02228
    Location:1 → 91
    Gag_p19; Major core protein p19

  3. NP_955618.1 p24 CA

    UniProtKB/TrEMBL
    I6T2E6, I6T2F4, I6T2F9, I6T2G4, I6T2G9, I6T2H3, I6TDQ9, I6TDR3, I6TDR7, I6TDS1, I6TDS5, I6TDS7, I6TWI8, I6TWJ3, I6TWJ9, I6TWK8, I6TWL4, I6U4F7, I6U4G1, I6U4G5, I6U4H4, I6U8C9, I6U8D2, I6U8E0, I6U8E3
    Conserved Domains (1) summary
    pfam00607
    Location:17 → 214
    Gag_p24; gag gene protein p24 (core nucleocapsid protein)
Nucleotide Protein
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