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Gucy2e guanylate cyclase 2e [ Mus musculus (house mouse) ]

Gene ID: 14919, updated on 10-Oct-2019

Summary

Official Symbol
Gucy2eprovided by MGI
Official Full Name
guanylate cyclase 2eprovided by MGI
Primary source
MGI:MGI:105123
See related
Ensembl:ENSMUSG00000020890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GC1; GC-E; ROS-GC1
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See Gucy2e in Genome Data Viewer
Location:
11 B3; 11 42.51 cM
Exon count:
18
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69218117..69237279, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69031619..69050524, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene arachidonate 8-lipoxygenase Neighboring gene U6 spliceosomal RNA Neighboring gene predicted gene, 40039

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
natriuretic peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
photoreceptor outer segment membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
guanylyl cyclase GC-E
Names
guanylyl cyclase 2e
NP_032218.2
XP_006532307.1
XP_030101438.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008192.3NP_032218.2  guanylyl cyclase GC-E precursor

    See identical proteins and their annotated locations for NP_032218.2

    Status: VALIDATED

    Source sequence(s)
    AL645527, BB591650, BC057954
    Consensus CDS
    CCDS24887.1
    UniProtKB/Swiss-Prot
    P52785
    Related
    ENSMUSP00000021259.2, ENSMUST00000021259.8
    Conserved Domains (6) summary
    cd06371
    Location:58434
    PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    smart00044
    Location:8481039
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:539814
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam00211
    Location:8741061
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:75411
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:823868
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    69218117..69237279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245578.1XP_030101438.1  guanylyl cyclase GC-E isoform X1

  2. XM_006532244.3XP_006532307.1  guanylyl cyclase GC-E isoform X2

    See identical proteins and their annotated locations for XP_006532307.1

    UniProtKB/Swiss-Prot
    P52785
    Related
    ENSMUSP00000104304.1, ENSMUST00000108664.1
    Conserved Domains (6) summary
    cd06371
    Location:58434
    PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    smart00044
    Location:8481039
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:539814
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam00211
    Location:8741061
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:75411
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:823868
    HNOBA; Heme NO binding associated
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