U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gag Pr65 [ Moloney murine leukemia virus ]

Gene ID: 1491870, updated on 18-Aug-2023

Summary

Go to the top of the page Help
Gene symbol
gag
Gene description
Pr65
Locus tag
MLVgp8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Moloney murine leukemia virus
Lineage
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus; Murine leukemia virus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_001501.1 (357..1973)

NC_001501.1Genomic Context describing neighboring genes Neighboring gene gPr80 Neighboring gene Pr180 Neighboring gene Neighboring gene

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001501.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phosphorylation Requirement of Murine Leukemia Virus p12. Brzezinski JD, et al. J Virol, 2016 Dec 15. PMID 27707931, Free PMC Article
  2. Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12. Brzezinski JD, et al. J Virol, 2016 Dec 15. PMID 27707926, Free PMC Article
  3. The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex. Usami Y, et al. J Virol, 2014 Mar. PMID 24403584, Free PMC Article
  4. The retrovirus MA and PreTM proteins follow immature MLV cores. Andersen KB. Virus Res, 2013 Aug. PMID 23643491
  5. A guanosine-centric mechanism for RNA chaperone function. Grohman JK, et al. Science, 2013 Apr 12. PMID 23470731, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation requirement of murine leukemia virus p12 virus p12 protein necessary for the host chromatin binding was elucidated.
    Title: Phosphorylation Requirement of Murine Leukemia Virus p12.
  2. The structure of the minimal sequence of the murine leukemia virus p12 protein necessary for the host chromatin binding was elucidated.
    Title: Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12.
  3. The N-terminal intracellular domain of the glycoGag is responsible for its effect on HIV-1 infectivity.
    Title: The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex.
  4. Authors found that mature Gag proteins MA and TM were bound to the immature core consisting of the Gag polyprotein (PrGag) and viral RNA (vRNA).
    Title: The retrovirus MA and PreTM proteins follow immature MLV cores.
  5. in presence of nucleocapsid (NC) chaperone, RNA dimerization occurred rapidly through a single structural intermediate; NC interacted primarily with guanosine residues; results show RNA chaperones can simplify RNA folding landscapes by weakening intramolecular interactions involving guanosine
    Title: A guanosine-centric mechanism for RNA chaperone function.
  6. selective packaging of dimeric RNA is explained by the nucleic acid binding domain derived from Gag binding within the virus to the sequence UCUG-UR-UCUG
    Title: Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome.
  7. Basal budding and replication of the murine leukemia virus are independent of the gag L domains
    Title: Basal budding and replication of the murine leukemia virus are independent of the gag L domains.
  8. Abl protein contribute to proper localization by playing a dominant role in trafficking of the v-Abl molecule
    Title: Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV.
  9. results suggest a cooperative effect of p12 and capsid during the early events of MLV replication
    Title: Cooperative effect of gag proteins p12 and capsid during early events of murine leukemia virus replication.
  10. interaction of Gag with Tsg101 and Alix favors budding from the plasma membrane and relieves a requirement for ubiquitination by Nedd4
    Title: Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
Pr65
Names
p15 MA
pp12
p30 CA
p10 NC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001501.1 Reference assembly

    Range
    357..1973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057934.1 Pr65 [Moloney murine leukemia virus]

    See identical proteins and their annotated locations for NP_057934.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03332, Q9WJP4
    UniProtKB/TrEMBL
    A0A126QCH7
    Conserved Domains (4) summary
    smart00343
    Location:503 → 519
    ZnF_C2HC; zinc finger
    pfam01140
    Location:2 → 131
    Gag_MA; Matrix protein (MA), p15
    pfam01141
    Location:132 → 215
    Gag_p12; Gag polyprotein, inner coat protein p12
    pfam02093
    Location:226 → 433
    Gag_p30; Gag P30 core shell protein

  2. NP_955583.1 p15 MA

    Conserved Domains (1) summary
    pfam01140
    Location:1 → 130
    Gag_MA; Matrix protein (MA), p15

  3. NP_955584.1 pp12

    Conserved Domains (1) summary
    pfam01141
    Location:1 → 84
    Gag_p12; Gag polyprotein, inner coat protein p12

  4. NP_955585.1 p30 CA

    UniProtKB/TrEMBL
    Q6JWR0
    Conserved Domains (1) summary
    pfam02093
    Location:11 → 218
    Gag_p30; Gag P30 core shell protein

  5. NP_955586.1 p10 NC

    UniProtKB/TrEMBL
    Q85655
    Conserved Domains (2) summary
    PTZ00368
    Location:15 → 50
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    smart00343
    Location:25 → 41
    ZnF_C2HC; zinc finger
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous