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Thumpd3 THUMP domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 14911, updated on 4-Nov-2022

Summary

Official Symbol
Thumpd3provided by MGI
Official Full Name
THUMP domain containing 3provided by MGI
Primary source
MGI:MGI:1277973
See related
Ensembl:ENSMUSG00000030264 AllianceGenome:MGI:1277973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtrosa26as; Gt(ROSA)26asSor
Summary
Predicted to enable tRNA (guanine) methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation. Predicted to be located in cytosol and nucleolus. Is expressed in central nervous system; craniocervical region bone; and sensory organ. Orthologous to human THUMPD3 (THUMP domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 10.3), placenta adult (RPKM 8.3) and 25 other tissues See more
Orthologs
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Genomic context

See Thumpd3 in Genome Data Viewer
Location:
6 E3; 6 52.73 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113023263..113045239)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113046302..113068278)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23244 Neighboring gene predicted gene, 43868 Neighboring gene gene trap ROSA 26, Philippe Soriano Neighboring gene predicted gene, 22591 Neighboring gene SET domain containing 5 Neighboring gene lipoma HMGIC fusion partner-like protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA (guanine-N2-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA N2-guanine methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tRNA (guanine(6)-N2)-methyltransferase THUMP3; THUMP domain-containing protein 3
Names
gene trap ROSA 26 antisense, Philippe Soriano
gtROSA26asSor
NP_001342195.1
NP_032214.1
XP_006505641.1
XP_006505642.1
XP_036021758.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355266.2NP_001342195.1  tRNA (guanine(6)-N2)-methyltransferase THUMP3

    Status: VALIDATED

    Source sequence(s)
    AC155722
    Consensus CDS
    CCDS20410.1
    UniProtKB/Swiss-Prot
    Q9D3P0
    Conserved Domains (2) summary
    cd11715
    Location:42288
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    pfam01170
    Location:295480
    UPF0020; Putative RNA methylase family UPF0020
  2. NM_001409954.1NP_001396883.1  tRNA (guanine(6)-N2)-methyltransferase THUMP3

    Status: VALIDATED

    Source sequence(s)
    AC155722
    UniProtKB/Swiss-Prot
    Q9D3P0
  3. NM_001409955.1NP_001396884.1  tRNA (guanine(6)-N2)-methyltransferase THUMP3

    Status: VALIDATED

    Source sequence(s)
    AC155722
    UniProtKB/Swiss-Prot
    Q9D3P0
  4. NM_008188.4NP_032214.1  tRNA (guanine(6)-N2)-methyltransferase THUMP3

    Status: VALIDATED

    Source sequence(s)
    AC155722
    Consensus CDS
    CCDS20410.1
    UniProtKB/Swiss-Prot
    P97770, Q9D3P0
    Related
    ENSMUSP00000032398.9, ENSMUST00000032398.15
    Conserved Domains (2) summary
    cd11715
    Location:42288
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    pfam01170
    Location:295480
    UPF0020; Putative RNA methylase family UPF0020

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113023263..113045239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505579.3XP_006505642.1  THUMP domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    P97770
    Conserved Domains (2) summary
    cd11715
    Location:42288
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    pfam01170
    Location:295480
    UPF0020; Putative RNA methylase family UPF0020
  2. XM_006505578.4XP_006505641.1  THUMP domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    P97770
    Conserved Domains (2) summary
    cd11715
    Location:42288
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    pfam01170
    Location:295480
    UPF0020; Putative RNA methylase family UPF0020
  3. XM_036165865.1XP_036021758.1  THUMP domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9D3P0
    Conserved Domains (2) summary
    cd11715
    Location:42288
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    pfam01170
    Location:295480
    UPF0020; Putative RNA methylase family UPF0020