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ZNF362 zinc finger protein 362 [ Homo sapiens (human) ]

Gene ID: 149076, updated on 5-May-2024

Summary

Official Symbol
ZNF362provided by HGNC
Official Full Name
zinc finger protein 362provided by HGNC
Primary source
HGNC:HGNC:18079
See related
Ensembl:ENSG00000160094 AllianceGenome:HGNC:18079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RN; lin-29
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 4.1), kidney (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

Location:
1p35.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (33127522..33300719)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32987140..33162335)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33722093..33766320)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903969 Neighboring gene uncharacterized LOC105378635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33549697-33550196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33557899-33558556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 706 Neighboring gene antizyme inhibitor 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:33592415-33593614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33605527-33606126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33606727-33607326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33628780-33629512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33629513-33630245 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7027 Neighboring gene tripartite motif containing 62 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 618 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7054 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33685009-33685609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33685744-33686528 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33709758-33710342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 622 Neighboring gene Sharpr-MPRA regulatory region 4113 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33729134-33729634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33734235-33734736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33760897-33761407 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:33764372-33764552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33764984-33765933 Neighboring gene MPRA-validated peak168 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33795184-33795684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33795685-33796185 Neighboring gene alpha 1,3-galactosyltransferase 2 Neighboring gene microRNA 3605 Neighboring gene polyhomeotic homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25476, MGC138318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 362
Names
rotund homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370212.1NP_001357141.1  zinc finger protein 362

    Status: VALIDATED

    Source sequence(s)
    AL513327
    Consensus CDS
    CCDS377.1
    UniProtKB/Swiss-Prot
    Q5T0B9, Q8WYU4
    Related
    ENSP00000362527.5, ENST00000373428.5
    Conserved Domains (5) summary
    COG5189
    Location:307359
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:27125
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:255277
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:269294
    zf-H2C2_2; Zinc-finger double domain
  2. NM_152493.3NP_689706.2  zinc finger protein 362

    See identical proteins and their annotated locations for NP_689706.2

    Status: VALIDATED

    Source sequence(s)
    AF318356, AL513327, AW204855, BF743001, BX283663
    Consensus CDS
    CCDS377.1
    UniProtKB/Swiss-Prot
    Q5T0B9, Q8WYU4
    Related
    ENSP00000446335.1, ENST00000539719.6
    Conserved Domains (5) summary
    COG5189
    Location:307359
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:27125
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:255277
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:269294
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    33127522..33300719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447108.1XP_047303064.1  zinc finger protein 362 isoform X1

    Conserved Domains (5) summary
    COG5189
    Location:325377
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:45143
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:275295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273295
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:287312
    zf-H2C2_2; Zinc-finger double domain
  2. XM_047447107.1XP_047303063.1  zinc finger protein 362 isoform X1

    Conserved Domains (5) summary
    COG5189
    Location:325377
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:45143
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:275295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273295
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:287312
    zf-H2C2_2; Zinc-finger double domain
  3. XM_047447110.1XP_047303066.1  zinc finger protein 362 isoform X4

  4. XM_005270507.3XP_005270564.1  zinc finger protein 362 isoform X3

    See identical proteins and their annotated locations for XP_005270564.1

    Conserved Domains (5) summary
    COG5189
    Location:294346
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:14112
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:244264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:242264
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:256281
    zf-H2C2_2; Zinc-finger double domain
  5. XM_047447109.1XP_047303065.1  zinc finger protein 362 isoform X2

    UniProtKB/Swiss-Prot
    Q5T0B9, Q8WYU4
  6. XM_005270508.6XP_005270565.1  zinc finger protein 362 isoform X3

    See identical proteins and their annotated locations for XP_005270565.1

    Conserved Domains (5) summary
    COG5189
    Location:294346
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:14112
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:244264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:242264
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:256281
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    32987140..33162335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334631.1XP_054190606.1  zinc finger protein 362 isoform X1

  2. XM_054334630.1XP_054190605.1  zinc finger protein 362 isoform X1

  3. XM_054334635.1XP_054190610.1  zinc finger protein 362 isoform X4

  4. XM_054334633.1XP_054190608.1  zinc finger protein 362 isoform X3

  5. XM_054334632.1XP_054190607.1  zinc finger protein 362 isoform X2

    UniProtKB/Swiss-Prot
    Q5T0B9, Q8WYU4
  6. XM_054334634.1XP_054190609.1  zinc finger protein 362 isoform X3