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GLIS1 GLIS family zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 148979, updated on 17-Sep-2024

Summary

Official Symbol
GLIS1provided by HGNC
Official Full Name
GLIS family zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:29525
See related
Ensembl:ENSG00000174332 MIM:610378; AllianceGenome:HGNC:29525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GLIS1 in Genome Data Viewer
Location:
1p32.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (53506239..53739164, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (53388327..53622016, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53971912..54204837, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378733 Neighboring gene Sharpr-MPRA regulatory region 5491 Neighboring gene solute carrier family 25 member 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53928578-53929106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53934837-53935376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53935377-53935914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53949500-53950120 Neighboring gene DMRT like family B with proline rich C-terminal 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53966190-53967030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53969230-53969793 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53972264-53972790 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53972791-53973317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53992273-53992776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53993281-53993784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54005067-54006034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54006035-54007002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54011803-54012302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54042179-54042808 Neighboring gene MPRA-validated peak234 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:54082618-54082784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54086231-54086735 Neighboring gene Sharpr-MPRA regulatory region 11088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54150404-54151233 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54151234-54152062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54159647-54160273 Neighboring gene RNA, U7 small nuclear 95 pseudogene Neighboring gene MPRA-validated peak235 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54181253-54181752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54204253-54204971 Neighboring gene uncharacterized LOC124904179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54236211-54236773 Neighboring gene small nucleolar RNA SNORA58 Neighboring gene NDC1 transmembrane nucleoporin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
EBI GWAS Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ36155

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger protein GLIS1
Names
GLI-similar 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367484.1NP_001354413.1  zinc finger protein GLIS1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105280, AL049745, AL591720
    Consensus CDS
    CCDS90959.1
    UniProtKB/TrEMBL
    A0A0D9SEX9
    Related
    ENSP00000486112.1, ENST00000628545.2
    Conserved Domains (2) summary
    COG5048
    Location:435514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:439461
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001390836.1NP_001377765.1  zinc finger protein GLIS1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105280, AL049745, AL591720
    Conserved Domains (2) summary
    COG5048
    Location:447522
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450469
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001390837.1NP_001377766.1  zinc finger protein GLIS1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105280, AL049745, AL591720
    Consensus CDS
    CCDS90959.1
    UniProtKB/TrEMBL
    A0A0D9SEX9
    Conserved Domains (2) summary
    COG5048
    Location:435514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:439461
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001390838.1NP_001377767.1  zinc finger protein GLIS1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC105280, AL049745, AL591720
    Conserved Domains (2) summary
    COG5048
    Location:435514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:439461
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_147193.4NP_671726.2  zinc finger protein GLIS1 isoform 1

    See identical proteins and their annotated locations for NP_671726.2

    Status: VALIDATED

    Source sequence(s)
    AC105280, AL049745, AL591720
    Consensus CDS
    CCDS582.1
    UniProtKB/Swiss-Prot
    Q2M3G9, Q8N9V9, Q8NBF1
    Related
    ENSP00000309653.2, ENST00000312233.4
    Conserved Domains (3) summary
    COG5048
    Location:260339
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278305
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    53506239..53739164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000409.2XP_016855898.1  zinc finger protein GLIS1 isoform X1

  2. XM_017000411.2XP_016855900.1  zinc finger protein GLIS1 isoform X3

  3. XM_047447071.1XP_047303027.1  zinc finger protein GLIS1 isoform X1

  4. XM_047447086.1XP_047303042.1  zinc finger protein GLIS1 isoform X2

  5. XM_047447085.1XP_047303041.1  zinc finger protein GLIS1 isoform X2

  6. XM_017000412.2XP_016855901.1  zinc finger protein GLIS1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    53388327..53622016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334608.1XP_054190583.1  zinc finger protein GLIS1 isoform X1

  2. XM_054334611.1XP_054190586.1  zinc finger protein GLIS1 isoform X3

  3. XM_054334610.1XP_054190585.1  zinc finger protein GLIS1 isoform X2

  4. XM_054334609.1XP_054190584.1  zinc finger protein GLIS1 isoform X2

  5. XM_054334612.1XP_054190587.1  zinc finger protein GLIS1 isoform X4