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GLIS1 GLIS family zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 148979, updated on 21-Dec-2019

Summary

Official Symbol
GLIS1provided by HGNC
Official Full Name
GLIS family zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:29525
See related
Ensembl:ENSG00000174332 MIM:610378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GLIS1 in Genome Data Viewer
Location:
1p32.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (53506233..53739171, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53971904..54203748, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378733 Neighboring gene solute carrier family 25 member 3 pseudogene 1 Neighboring gene DMRT like family B with proline rich C-terminal 1 Neighboring gene RNA, U7 small nuclear 95 pseudogene Neighboring gene NDC1 transmembrane nucleoporin Neighboring gene ribosomal protein L37 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
NHGRI GWA Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36155

Gene Ontology Provided by GOA

Process Evidence Code Pubs
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger protein GLIS1
Names
GLI-similar 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367484.1NP_001354413.1  zinc finger protein GLIS1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105280, AL049745, AL591720
    Related
    ENSP00000486112.1, ENST00000628545.1
  2. NM_147193.2NP_671726.2  zinc finger protein GLIS1 isoform 1

    See identical proteins and their annotated locations for NP_671726.2

    Status: VALIDATED

    Source sequence(s)
    AK093474, AL049745, AL591720, BC101799
    Consensus CDS
    CCDS582.1
    UniProtKB/Swiss-Prot
    Q8NBF1
    Related
    ENSP00000309653.2, ENST00000312233.4
    Conserved Domains (3) summary
    COG5048
    Location:260339
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278305
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    53506233..53739171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000409.1XP_016855898.1  zinc finger protein GLIS1 isoform X2

  2. XM_017000411.1XP_016855900.1  zinc finger protein GLIS1 isoform X3

  3. XM_017000410.1XP_016855899.1  zinc finger protein GLIS1 isoform X1

    UniProtKB/TrEMBL
    A0A0D9SEX9
  4. XM_017000412.1XP_016855901.1  zinc finger protein GLIS1 isoform X4

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