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NS1 nonstructural protein [ Minute virus of mice ]

Gene ID: 1489590, updated on 6-Oct-2023

Summary

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Gene symbol
NS1
Gene description
nonstructural protein
Locus tag
MMVgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Minute virus of mice (strain: MVM(p))
Lineage
Viruses; ssDNA viruses; Parvoviridae; Parvovirinae; Protoparvovirus
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Genomic context

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Sequence:
NC_001510.1 (114..2279)

NC_001510.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001510.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The NS1 protein of the parvovirus MVM Aids in the localization of the viral genome to cellular sites of DNA damage.
    Title: The NS1 protein of the parvovirus MVM Aids in the localization of the viral genome to cellular sites of DNA damage.
  2. NS1 N-terminal domain is for dsDNA binding, ssDNA binding and cleavage and nuclear localization.
    Title: Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding.
  3. The authors show that Minute virus of mice infection and/or NS1 protein expression in permissive transformed rat fibroblast cells leads to apoptosis in wild type and p53(-/-) cells.
    Title: Minute virus of mice (MVMp) infection and NS1 expression induce p53 independent apoptosis in transformed rat fibroblast cells.
  4. that NS1 may serve as a form of chromatin to protect and tailor the environment of replicating genomes.
    Title: Replication initiator protein NS1 of the parvovirus minute virus of mice binds to modular divergent sites distributed throughout duplex viral DNA.
  5. cytotoxic adaptor function of NS1 was confirmed with fusion peptides, where the tropomyosin-binding domain of NS1 and casein kinase II alpha are physically linked
    Title: A viral adaptor protein modulating casein kinase II activity induces cytopathic effects in permissive cells.
  6. Parvovirus-induced cytopathic effect (CPE) is mediated by NS1 interference with intracellular murine casein kinase II signaling.
    Title: NS1 interaction with CKII alpha: novel protein complex mediating parvovirus-induced cytotoxicity.
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General gene information

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Homology

General protein information

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Preferred Names
nonstructural protein
NP_041242.1
  • putative

VOG classification

Description:

  • VOGs0109 [L] Parvoviridae non-structural proteins NS1/Rep
  • DNA Replication, Repair and Nucleotide Metabolism
NP_041243.1

VOG classification

Description:

  • VOGs0109 [L] Parvoviridae non-structural proteins NS1/Rep
  • DNA Replication, Repair and Nucleotide Metabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001510.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_041243.1 nonstructural protein [Minute virus of mice]

    See identical proteins and their annotated locations for NP_041243.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03134
    UniProtKB/TrEMBL
    B7U876
    Conserved Domains (3) summary
    pfam01057
    Location:277 → 547
    Parvo_NS1; Parvovirus non-structural protein NS1
    pfam12117
    Location:552 → 672
    DUF3580; Protein of unknown function (DUF3580)
    pfam12433
    Location:185 → 258
    PV_NSP1; Parvovirus non-structural protein 1

  2. NP_041242.1 nonstructural protein [Minute virus of mice]

    See identical proteins and their annotated locations for NP_041242.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q84363, Q84365
    Conserved Domains (3) summary
    pfam01057
    Location:326 → 596
    Parvo_NS1; Parvovirus non-structural protein NS1
    pfam12117
    Location:601 → 721
    DUF3580; Protein of unknown function (DUF3580)
    pfam12433
    Location:234 → 307
    PV_NSP1; Parvovirus non-structural protein 1
Nucleotide Protein
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