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Jvgp5 hypothetical protein [ JC polyomavirus ]

Gene ID: 1489517, updated on 18-Aug-2023
Gene symbol
Jvgp5
Gene description
hypothetical protein
Locus tag
Jvgp5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
JC polyomavirus (strain: Mad1)
Lineage
Viruses; dsDNA viruses, no RNA stage; Polyomaviridae
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Sequence:
NC_001699.1 (2603..5013, complement)

NC_001699.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_001699.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy. Takahashi K, et al. J Virol, 2017 Jan 1. PMID 27795410, Free PMC Article
  2. Polyomavirus T antigens activate an antiviral state. Giacobbi NS, et al. Virology, 2015 Feb. PMID 25589241, Free PMC Article
  3. Molecular interplay between T-Antigen and splicing factor, arginine/serine-rich 1 (SRSF1) controls JC virus gene expression in glial cells. Craigie M, et al. Virol J, 2015 Nov 24. PMID 26596376, Free PMC Article
  4. Genomic structure of human polyoma virus JC: nucleotide sequence of the region containing replication origin and small-T-antigen gene. Miyamura T, et al. J Virol, 1983 Jan. PMID 6296460, Free PMC Article
  5. p53 inhibits JC virus DNA replication in vivo and interacts with JC virus large T-antigen. Staib C, et al. Virology, 1996 May 1. PMID 8623534

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The V392G amino acid substitution in T antigen identified frequently in progressive multifocal leukoencephalopathy (PML) lesions has a function in suppressing JC virus replication, but the frequency of the mutation was restricted and its role in PML lesions was limited.
    Title: Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy.
  2. These findings have revealed a molecular interplay between cellular SRSF1 and viral T-antigen in controlling JC virus gene expression.
    Title: Molecular interplay between T-Antigen and splicing factor, arginine/serine-rich 1 (SRSF1) controls JC virus gene expression in glial cells.
  3. Expression of T antigen from SV40, Human Polyomaviruses BK or JC upregulate production of ISGs.
    Title: Polyomavirus T antigens activate an antiviral state.
  4. VP2 and VP3 enhance large T antigen binding to the origin of viral DNA replication.
    Title: Human polyoma JC virus minor capsid proteins, VP2 and VP3, enhance large T antigen binding to the origin of viral DNA replication: evidence for their involvement in regulation of the viral DNA replication.
  5. Authors found that JC virus T antigen enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2.
    Title: Relationship between methyl CpG binding protein 2 and JC viral proteins.
  6. Data suggest that by investigating the interplay between large T-antigen (T-Ag) and Bag3 may provid better understanding on the development of JCV-associated diseases.
    Title: Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag.
  7. This study showed that BAG3 protein is downregulated upon JC virus (JCV) infection and that this effect is mediated by JCV T-antigen via repression of the BAG3 promoter.
    Title: Evidence for modulation of BAG3 by polyomavirus JC early protein.
  8. These observations unravel the interplay between beta-catenin and Rac1 that is initiated by T-Ag and results in stabilization of beta-catenin and its presence in cell membrane ruffles.
    Title: A novel role of Rac1 GTPase in JCV T-antigen-mediated beta-catenin stabilization.
  9. Data show that JC polyomavirus T-antigen inhibits homologous recombination DNA repair by binding insulin receptor substrate 1, which then translocates to the nucleus and binds Rad51 at the site of damaged DNA.
    Title: T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Preferred Names
hypothetical protein
NP_043512.1

VOG classification

Description:

  • VOGd0053 [L] Large tumor antigen
  • DNA Replication, Repair and Nucleotide Metabolism

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001699.1 Reference assembly

    Range
    2603..5013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_043512.1 hypothetical protein [JC polyomavirus]

    See identical proteins and their annotated locations for NP_043512.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03072
    UniProtKB/TrEMBL
    F6LRU3, F6LRW1, F6LS15, F6LSW5, F6LTD3, O92721, Q4R2W4, Q6L813, Q6L849, Q6L861, Q783D1, Q8JJJ0, Q8JZJ2, Q91DF5, Q91NP7
    Conserved Domains (1) summary
    PHA02624
    Location:1 → 636
    PHA02624; large T antigen; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03072.1

Gene LinkOut

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Molecular Biology Databases
Research Materials