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E2 E2 protein [ human papillomavirus 18 ]

Gene ID: 1489085, updated on 18-Aug-2023

Summary

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Gene symbol
E2
Gene description
E2 protein
Locus tag
HpV18gp4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
human papillomavirus 18
Lineage
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus
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Genomic context

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Sequence:
NC_001357.1 (2817..3914)

NC_001357.1Genomic Context describing neighboring genes Neighboring gene E6 protein Neighboring gene E7 protein Neighboring gene E1 Neighboring gene E4 protein Neighboring gene E5 protein Neighboring gene L2 protein Neighboring gene major capsid L1 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001357.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study. Collins SI, et al. Cancer Res, 2009 May 1. PMID 19401452
  2. Direct activation of caspase 8 by the proapoptotic E2 protein of HPV18 independent of adaptor proteins. Thierry F, et al. Cell Death Differ, 2008 Sep. PMID 18421300
  3. Insights into the mechanism of human papillomavirus E2-induced procaspase-8 activation and cell death. Singh N, et al. Sci Rep, 2016 Feb 24. PMID 26906543, Free PMC Article
  4. Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. Tan CL, et al. Cell Cycle, 2015. PMID 25789401, Free PMC Article
  5. HPV-18 E2^E4 chimera: 2 new spliced transcripts and proteins induced by keratinocyte differentiation. Tan CL, et al. Virology, 2012 Jul 20. PMID 22541938

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct non-homotypic interactions of HPV18 E2 transactivation domain (TAD) with alpha2/alpha5 helices of procaspase-8 death effector domain-B (DED-B) mediate cell death in HEK293 cells.
    Title: Insights into the mechanism of human papillomavirus E2-induced procaspase-8 activation and cell death.
  2. Suggest human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy in HPV-induced cervical cancer.
    Title: Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy.
  3. Both E2;E4 transcripts are up-regulated by keratinocyte differentiation.
    Title: HPV-18 E2^E4 chimera: 2 new spliced transcripts and proteins induced by keratinocyte differentiation.
  4. These results suggest that the SWI/SNF complex is involved in human papillomavirus E2-driven transcription and DNA replication via interaction with E2.
    Title: hSNF5 is required for human papillomavirus E2-driven transcriptional activation and DNA replication.
  5. The expression of all E8wedgeE2C proteins inhibited the growth of HeLa cells.
    Title: Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein.
  6. E2-mediated accumulation of Skp2, together with E2 degradation leading to release of E6 and E7 inhibition, could induce premature S-phase entry in HPV-infected cells, pointing to a direct role of E2 in the early steps of HPV-mediated transformation.
    Title: The human papillomavirus type 18 E2 protein is a cell cycle-dependent target of the SCFSkp2 ubiquitin ligase.
  7. Among women with an intact E2 gene in their baseline sample, the median time to first detection of E2 disruption was also shorter for those who tested positive for HPV18 than HPV16.
    Title: Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study.
  8. The E2 protein of human papillomavirus type 18 triggers apoptosis by assembling cytoplasmic filaments together with caspase 8, in which its efficient self-activation occurs.
    Title: Direct activation of caspase 8 by the proapoptotic E2 protein of HPV18 independent of adaptor proteins.
  9. Study identified 55 new E2-activated genes, among which is a new cluster of p63 target genes involved in cell adhesion.
    Title: A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells.
  10. Presence of full-length E2 from high-risk HPV-18 (but not from low-risk HPV-6 or HPV-11) in different cell lines promotes a mitotic block followed by metaphase-specific apoptosis, and could play a role in the oncogenic potential of HPV-18.
    Title: High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability.
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General protein information

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Preferred Names
E2 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001357.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040313.1 E2 protein [human papillomavirus 18]

    See identical proteins and their annotated locations for NP_040313.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06790
    Conserved Domains (2) summary
    pfam00508
    Location:6 → 200
    PPV_E2_N; E2 (early) protein, N terminal
    pfam00511
    Location:288 → 363
    PPV_E2_C; E2 (early) protein, C terminal
Nucleotide Protein
Heading Accession and Version

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