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ANKRD35 ankyrin repeat domain 35 [ Homo sapiens (human) ]

Gene ID: 148741, updated on 13-May-2022

Summary

Official Symbol
ANKRD35provided by HGNC
Official Full Name
ankyrin repeat domain 35provided by HGNC
Primary source
HGNC:HGNC:26323
See related
Ensembl:ENSG00000198483 AllianceGenome:HGNC:26323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in skin (RPKM 27.5), esophagus (RPKM 8.5) and 5 other tissues See more
Orthologs
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Genomic context

See ANKRD35 in Genome Data Viewer
Location:
1q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145866564..145885866, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144983377..145002686, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145549209..145568522)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 17 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene microRNA 6736 Neighboring gene uncharacterized LOC107985593 Neighboring gene integrin subunit alpha 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular ankyrin repeat domain 35 protein (ANKRD35) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PIAS3

Homology

Clone Names

  • FLJ25124, MGC126667, MGC126669

General protein information

Preferred Names
ankyrin repeat domain-containing protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001280799.2NP_001267728.1  ankyrin repeat domain-containing protein 35 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC243547, AK294308, DA399526, HY327286
    Consensus CDS
    CCDS72868.1
    UniProtKB/TrEMBL
    B4DFX6, F6XZD3
    Related
    ENSP00000442671.2, ENST00000544626.2
    Conserved Domains (4) summary
    cd00204
    Location:24136
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:34126
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:841
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:2960
    ANK; ANK repeat [structural motif]
  2. NM_144698.5NP_653299.4  ankyrin repeat domain-containing protein 35 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC243547, AK294308, BC101618, DA399526, HY327286
    Consensus CDS
    CCDS72867.1
    UniProtKB/Swiss-Prot
    Q8N283
    UniProtKB/TrEMBL
    B4DFX6
    Related
    ENSP00000347802.4, ENST00000355594.9
    Conserved Domains (6) summary
    COG1340
    Location:676968
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00204
    Location:81206
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05278
    Location:803950
    PEARLI-4; Arabidopsis phospholipase-like protein (PEARLI 4)
    pfam12796
    Location:58150
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2474
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:5384
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    145866564..145885866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    144983377..145002686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)