US3 tegument protein; phosphorylates nuclear egress lamina protein; mediates phosphorylation of HDAC1 and HDAC2 and other cellular and viral proteins; involved in protein phosphorylation; involved in apoptosis; involved in nuclear egress [Human alphaherpesvirus 2] - Gene

Summary

Go to the top of the page Help

Gene symbol: US3
Gene description: tegument protein; phosphorylates nuclear egress lamina protein; mediates phosphorylation of HDAC1 and HDAC2 and other cellular and viral proteins; involved in protein phosphorylation; involved in apoptosis; involved in nuclear egress
Locus tag: HHV2p12
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Human alphaherpesvirus 2 (strain: HG52, acronym: HHV-2, acronym: HSV-2, nat-host: Homo sapiens)
Lineage: Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Sequence:: NC_001798.2 (136329..140059)

NC_001798.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001798.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The difference between HSV-1 and HSV-2 Us3 kinases appeared to be due to the fact that some Us3 phosphorylation sites in HSV-1 proteins are not conserved in the corresponding HSV-2 proteins.
Title: Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene.
These findings demonstrate that Us3 orthologues derived from distantly related alphaherpesviruses cause a disruption of PML protein nuclear bodies in a kinase- and proteasome-dependent manner but, do not target PML for degradation.
Title: The alphaherpesvirus serine/threonine kinase us3 disrupts promyelocytic leukemia protein nuclear bodies.
Herein the authors describe determinants of HSV-2 Us3-induced filamentous processes formation and present evidence for the presence of a leucine-rich nuclear export signal within HSV-2 Us3.
Title: Analysis of filamentous process induction and nuclear localization properties of the HSV-2 serine/threonine kinase Us3.
regulatory and functional effects differ from Us3 protein kinase in herpes simplex virus 1
Title: Differences in the regulatory and functional effects of the Us3 protein kinase activities of herpes simplex virus 1 and 2.
required for stable expression of UL46 and its association with virions, and phosphorylates Ul46 in vitro
Title: US3 protein kinase of herpes simplex virus type 2 is required for the stability of the UL46-encoded tegument protein and its association with virus particles.
These results suggest that the US3 protein kinase of HSV regulates virus-induced neuronal apoptosis in peripheral conduits and determines the neuroinvasive phenotype of HSV.
Title: Herpes simplex virus US3 protein kinase regulates virus-induced apoptosis in olfactory and vomeronasal chemosensory neurons in vivo.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

regulatory

Loc: 140054-140059 regulatory_class = polyA_signal_sequence

General protein information

Go to the top of the page Help

Preferred Names: tegument protein; phosphorylates nuclear egress lamina protein; mediates phosphorylation of HDAC1 and HDAC2 and other cellular and viral proteins; involved in protein phosphorylation; involved in apoptosis; involved in nuclear egress