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RL2 contains a RING finger; disrupts ND10; proteasome-dependent degradation of several cellular proteins; involved in gene regulation; involved in cellular protein degradation; involved in latency [ Human alphaherpesvirus 2 ]

Gene ID: 1487288, updated on 18-Aug-2023
Gene symbol
RL2
Gene description
contains a RING finger; disrupts ND10; proteasome-dependent degradation of several cellular proteins; involved in gene regulation; involved in cellular protein degradation; involved in latency
Locus tag
HHV2p76
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 2 (strain: HG52, acronym: HHV-2, acronym: HSV-2, nat-host: Homo sapiens)
Lineage
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Sequence:
NC_001798.2 (2303..5643)

NC_001798.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene virion protein; inhibits stress-induced translational arrest; related to eIF2 phosphatase regulatory subunit GADD34; binds protein phosphatase 1 to form a holoenzyme capable of dephosphorylating eIF2-alpha; involved in translational regulation Neighboring gene contains a signal peptide; complexed with envelope glycoprotein H; involved in cell entry; involved in cell-to-cell spread Neighboring gene involved in DNA repair Neighboring gene colocalizes with regulatory protein ICP22 and nuclear protein UL4 in small, dense nuclear bodies

Genomic Sequence:
NC_001798.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Interaction between the cellular E3 ubiquitin ligase SIAH-1 and the viral immediate-early protein ICP0 enables efficient replication of Herpes Simplex Virus type 2 in vivo. Czechowicz JS, et al. PLoS One, 2018. PMID 30080903, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

regulatory

  • Loc: 5638-5643 regulatory_class = polyA_signal_sequence

Repeated regions

  • Loc: 3471-3607 rpt_type = direct , rpt_type = tandem
  • Loc: 4653-4797 rpt_type = direct , rpt_type = tandem
Preferred Names
contains a RING finger; disrupts ND10; proteasome-dependent degradation of several cellular proteins; involved in gene regulation; involved in cellular protein degradation; involved in latency
Names
ubiquitin E3 ligase ICP0

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001798.2 Reference assembly

    Range
    2303..5643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137151.1 ubiquitin E3 ligase ICP0 [Human alphaherpesvirus 2]

    See identical proteins and their annotated locations for YP_009137151.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7G7P0M1, G9I221
    Conserved Domains (1) summary
    pfam00097
    Location:126 → 166
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases