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Gstp2 glutathione S-transferase, pi 2 [ Mus musculus (house mouse) ]

Gene ID: 14869, updated on 8-Feb-2024

Summary

Official Symbol
Gstp2provided by MGI
Official Full Name
glutathione S-transferase, pi 2provided by MGI
Primary source
MGI:MGI:95864
See related
Ensembl:ENSMUSG00000038155 AllianceGenome:MGI:95864
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gst3; Gst-3; GSTpiA
Summary
Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Predicted to be located in mitochondrion; nucleus; and plasma membrane. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cranium; eye; heart; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 669.0), stomach adult (RPKM 478.7) and 27 other tissues See more
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Genomic context

See Gstp2 in Genome Data Viewer
Location:
19 A; 19 3.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4090288..4092221, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4040288..4042221, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2517 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene glutathione S-transferase, pi 1 Neighboring gene STARR-seq mESC enhancer starr_45337 Neighboring gene STARR-positive B cell enhancer ABC_E5673 Neighboring gene glutathione S-transferase pi 3 Neighboring gene predicted gene, 42060

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-nitrosoglutathione binding ISO
Inferred from Sequence Orthology
more info
 
enables dinitrosyl-iron complex binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutathione derivative biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hepoxilin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of TRAF2-GSTP1 complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione S-transferase P 2
Names
GST YF-YF
GST class-pi
GST-piA
Gst p-2
gst P2
NP_861461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181796.2NP_861461.1  glutathione S-transferase P 2

    See identical proteins and their annotated locations for NP_861461.1

    Status: PROVISIONAL

    Source sequence(s)
    BC064781
    Consensus CDS
    CCDS29412.1
    UniProtKB/Swiss-Prot
    P46425, Q505C3
    UniProtKB/TrEMBL
    A0A494BAW2
    Related
    ENSMUSP00000038931.10, ENSMUST00000042700.12
    Conserved Domains (3) summary
    PTZ00057
    Location:6196
    PTZ00057; glutathione s-transferase; Provisional
    cd03210
    Location:84210
    GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
    cd03076
    Location:376
    GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4090288..4092221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)