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Gsx2 GS homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 14843, updated on 8-Feb-2024

Summary

Official Symbol
Gsx2provided by MGI
Official Full Name
GS homeobox 2provided by MGI
Primary source
MGI:MGI:95843
See related
Ensembl:ENSMUSG00000035946 AllianceGenome:MGI:95843
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gsh2; Gsh-2
Summary
Enables DNA binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of Notch signaling pathway; and regulation of respiratory gaseous exchange by nervous system process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; and neural ectoderm. Orthologous to human GSX2 (GS homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 1.5), CNS E11.5 (RPKM 1.5) and 4 other tissues See more
Orthologs
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Genomic context

See Gsx2 in Genome Data Viewer
Location:
5 C3.3; 5 39.55 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (75236262..75238554)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (75075601..75077893)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich hydrophobic domain 2 Neighboring gene retinoblastoma binding protein 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3584 Neighboring gene STARR-positive B cell enhancer ABC_E9644 Neighboring gene STARR-seq mESC enhancer starr_13419 Neighboring gene predicted gene, 19583 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, pseudogene Neighboring gene olfactory receptor 1401, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within GABAergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in generation of neurons IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hindbrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within olfactory bulb interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord association neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within subpallium development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within subpallium neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within telencephalon regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
GS homeobox 2
Names
genetic-screened homeobox 2
genomic screened homeo box 2
homeobox protein GSH-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133256.2NP_573555.1  GS homeobox 2

    See identical proteins and their annotated locations for NP_573555.1

    Status: PROVISIONAL

    Source sequence(s)
    AC161192
    Consensus CDS
    CCDS19350.1
    UniProtKB/Swiss-Prot
    P31316
    Related
    ENSMUSP00000036625.4, ENSMUST00000040477.4
    Conserved Domains (1) summary
    pfam00046
    Location:207259
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    75236262..75238554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)