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Gsx1 GS homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 14842, updated on 14-May-2024

Summary

Official Symbol
Gsx1provided by MGI
Official Full Name
GS homeobox 1provided by MGI
Primary source
MGI:MGI:95842
See related
Ensembl:ENSMUSG00000053129 AllianceGenome:MGI:95842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gsh1; Gsh-1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human GSX1 (GS homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 4.3), whole brain E14.5 (RPKM 3.1) and 3 other tissues See more
Orthologs
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Genomic context

See Gsx1 in Genome Data Viewer
Location:
5 G3; 5 86.79 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147125492..147127753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147188696..147190947)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) I polypeptide D Neighboring gene ribosomal protein S10, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_14868 Neighboring gene predicted gene, 34994 Neighboring gene predicted gene, 24556 Neighboring gene predicted gene, 38751

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within adenohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hypothalamus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spinal cord association neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
GS homeobox 1
Names
genomic screened homeo box 1
homeobox protein GSH-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008178.3NP_032204.1  GS homeobox 1

    See identical proteins and their annotated locations for NP_032204.1

    Status: VALIDATED

    Source sequence(s)
    AC115847
    Consensus CDS
    CCDS19877.1
    UniProtKB/Swiss-Prot
    P31315
    UniProtKB/TrEMBL
    B2RQ55
    Related
    ENSMUSP00000069728.6, ENSMUST00000065382.6
    Conserved Domains (1) summary
    pfam00046
    Location:150203
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147125492..147127753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)